The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis

Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood sa...

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Bibliographic Details
Published in:International Journal of Inflammation 2017-01, Vol.2017 (2017), p.51-56
Main Authors: Samsonova, Nataliya, Klimovich, Ludmila, Plyushch, Marina, Rogalskaya, Ekaterina, Yaroustovsky, Michael, Abramyan, Marina
Format: Article
Language:English
Subjects:
Adsorption
Bacteria
Bibliographic data bases
Biomarkers
Cardiac patients
Cardiovascular disease
Gram-negative bacteria
Infection
Inflammation
Intensive care
Laboratories
Microorganisms
Mortality
Neutrophils
Patients
Postoperative period
Sepsis
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Summary:Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin. Results. 83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia.
ISSN:2042-0099
2090-8040
2042-0099
DOI:10.1155/2017/3495293