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The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis
Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood sa...
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| Published in: | International Journal of Inflammation 2017-01, Vol.2017 (2017), p.51-56 |
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| container_end_page | 56 |
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| container_title | International Journal of Inflammation |
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| creator | Samsonova, Nataliya Klimovich, Ludmila Plyushch, Marina Rogalskaya, Ekaterina Yaroustovsky, Michael Abramyan, Marina |
| description | Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin. Results. 83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia. |
| doi_str_mv | 10.1155/2017/3495293 |
| format | article |
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L. ; B L Slomiany</contributor><creatorcontrib>Samsonova, Nataliya ; Klimovich, Ludmila ; Plyushch, Marina ; Rogalskaya, Ekaterina ; Yaroustovsky, Michael ; Abramyan, Marina ; Slomiany, B. L. ; B L Slomiany</creatorcontrib><description>Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin. Results. 83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p<0.05). Conclusions. EAA results should be interpreted with the level of neutrophil response. “Response” > 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia.</description><identifier>ISSN: 2042-0099</identifier><identifier>ISSN: 2090-8040</identifier><identifier>EISSN: 2042-0099</identifier><identifier>DOI: 10.1155/2017/3495293</identifier><identifier>PMID: 28487809</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Adsorption ; Bacteria ; Bibliographic data bases ; Biomarkers ; Cardiac patients ; Cardiovascular disease ; Gram-negative bacteria ; Infection ; Inflammation ; Intensive care ; Laboratories ; Microorganisms ; Mortality ; Neutrophils ; Patients ; Postoperative period ; Sepsis</subject><ispartof>International Journal of Inflammation, 2017-01, Vol.2017 (2017), p.51-56</ispartof><rights>Copyright © 2017 Michael Yaroustovsky et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Michael Yaroustovsky et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2017 Michael Yaroustovsky et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a702t-ff64737495204819d15c38ce8c0b1c47f119349e66bd1579ab80ffbfcee2ce913</citedby><cites>FETCH-LOGICAL-a702t-ff64737495204819d15c38ce8c0b1c47f119349e66bd1579ab80ffbfcee2ce913</cites><orcidid>0000-0002-1849-4745</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2407644065/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2407644065?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28487809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Slomiany, B. L.</contributor><contributor>B L Slomiany</contributor><creatorcontrib>Samsonova, Nataliya</creatorcontrib><creatorcontrib>Klimovich, Ludmila</creatorcontrib><creatorcontrib>Plyushch, Marina</creatorcontrib><creatorcontrib>Rogalskaya, Ekaterina</creatorcontrib><creatorcontrib>Yaroustovsky, Michael</creatorcontrib><creatorcontrib>Abramyan, Marina</creatorcontrib><title>The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis</title><title>International Journal of Inflammation</title><addtitle>Int J Inflam</addtitle><description>Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin. Results. 83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p<0.05). Conclusions. EAA results should be interpreted with the level of neutrophil response. “Response” > 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia.</description><subject>Adsorption</subject><subject>Bacteria</subject><subject>Bibliographic data bases</subject><subject>Biomarkers</subject><subject>Cardiac patients</subject><subject>Cardiovascular disease</subject><subject>Gram-negative bacteria</subject><subject>Infection</subject><subject>Inflammation</subject><subject>Intensive care</subject><subject>Laboratories</subject><subject>Microorganisms</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>Patients</subject><subject>Postoperative period</subject><subject>Sepsis</subject><issn>2042-0099</issn><issn>2090-8040</issn><issn>2042-0099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEolXpjTOyhISQYFs7iRObA9JSCiyqoIIijpbjjDcuWXuxs_34c_w2Jt3SdhEH8iEn9jPv2K_HWfaY0T3GON_PKav3i1LyXBb3su2clvmEUinv3_neynZTOqV4FRIf-TDbykUpakHldvbrpANyBGfQk2DJ5wvX6sGdAfkEqyGGZed68gXSMvgE5HsHnryFAeLCeefn5NC3YQgXzpOpwSg3XJJpSvryFZmiwDl548JCxx8QiQ0RI-06bMCUM986g6lQmGjfkkNrYdQADymNU5n5AXwap3KgIxDMcYw4-CGRczd05Cssk0uPsgdW9wl2r9ud7Nu7w5ODD5Ojz-9nB9Ojia5pPkysrcq6qEefaCmYbBk3hTAgDG2YKWvLmEQXoaoaHKqlbgS1trEGIDcgWbGTzda6bdCnahkdrutSBe3UVUeIc6Xj4EwPSrRcANe5BWnKphCCClE3wtqCmULiu5O9XmstV80CWoNrirrfEN0c8a5T83CmeEl5UUsUeH4tEMPPFaRBLVwy0PfaQ1glxYSUjHLGCkSf_oWehlX0aJXKS1pXZUkrfkvNNS7AeRswrxlF1ZTzkglWcYrU3j8ovFtYOBM8bi_2bwQ8uxPQge6HLoV-dbXrm-DLNWhiSCmCvTGDUTXWuRrrXF3XOeJP7hp4A_-pagRerIHO-Vafu_-UA2TA6luaVXVZjpv_cQ1oF93gbi08Rh3Oclrj0brSZPnYCMrQXJrTzR_OFK-K30fNIv4</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Samsonova, Nataliya</creator><creator>Klimovich, Ludmila</creator><creator>Plyushch, Marina</creator><creator>Rogalskaya, Ekaterina</creator><creator>Yaroustovsky, Michael</creator><creator>Abramyan, Marina</creator><general>Hindawi Limiteds</general><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1849-4745</orcidid></search><sort><creationdate>20170101</creationdate><title>The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis</title><author>Samsonova, Nataliya ; 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L.</au><au>B L Slomiany</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis</atitle><jtitle>International Journal of Inflammation</jtitle><addtitle>Int J Inflam</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>51</spage><epage>56</epage><pages>51-56</pages><issn>2042-0099</issn><issn>2090-8040</issn><eissn>2042-0099</eissn><abstract>Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin. Results. 83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p<0.05). Conclusions. EAA results should be interpreted with the level of neutrophil response. “Response” > 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>28487809</pmid><doi>10.1155/2017/3495293</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1849-4745</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adsorption Bacteria Bibliographic data bases Biomarkers Cardiac patients Cardiovascular disease Gram-negative bacteria Infection Inflammation Intensive care Laboratories Microorganisms Mortality Neutrophils Patients Postoperative period Sepsis |
| title | The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis |
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