Polymer-drug conjugates: revolutionizing nanotheranostic agents for diagnosis and therapy

Nanotheranostics, an amalgamation of therapeutic and diagnostic capabilities at the nanoscale, is revolutionizing personalized medicine. Polymer-drug conjugates (PDCs) stand at the forefront of this arena, offering a multifaceted approach to treat complex diseases such as cancer. This review explore...

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Bibliographic Details
Published in:Discover. Oncology 2024-11, Vol.15 (1), p.641-21, Article 641
Main Authors: Parashar, Ashish Kumar, Saraogi, Gaurav Kant, Jain, Pushpendra Kumar, Kurmi, Balakdas, Shrivastava, Vivek, Arora, Vandana
Format: Article
Language:English
Subjects:
Acids
Biodistribution
Brain cancer
Breast cancer
Cancer Research
Cancer therapies
Chemical bonds
Contrast agents
Drug delivery systems
Imaging agents
Integrated approach
Internal Medicine
Medicine
Medicine & Public Health
Molecular Medicine
Nanomedicine
Nanoparticles
Nanotheranostics
Oncology
Pancreatic cancer
Polyethylene glycol
Polymer-drug conjugates
Polymerization
Polymers
Precision medicine
Quantum dots
Radiotherapy
Review
Rheumatoid arthritis
Side effects
Surgical Oncology
Targeted drug delivery
Tomography
Vitamin B
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Summary:Nanotheranostics, an amalgamation of therapeutic and diagnostic capabilities at the nanoscale, is revolutionizing personalized medicine. Polymer-drug conjugates (PDCs) stand at the forefront of this arena, offering a multifaceted approach to treat complex diseases such as cancer. This review explores the recent advancements in PDCs, highlighting their design principles, working mechanisms, and the therapeutic applications. We discuss the incorporation of imaging agents into PDCs that allow for real-time monitoring of drug delivery and treatment efficacy. With the aim of improving patient care, the review examines how PDCs enable targeted drug delivery, minimize side effects, and provide valuable diagnostic data, hence enhancing the precision of medical interventions. We also address the challenges facing the clinical translation of PDCs, such as scalability, regulatory hurdles, and cost-effectiveness, providing a comprehensive outlook on the future of nanotheranostics in patient management.
ISSN:2730-6011
2730-6011
DOI:10.1007/s12672-024-01509-9