A systematic review and meta-analysis of long noncoding RNA linc-UBC1 expression and prognosis and clinicopathological phenotypes in human cancers

According to previous studies, linc-UBC1 is abnormally expressed in various human tumours. Nonetheless, the clinical significance and mechanism of linc-UBC1 in cancer remains unclear. In our present analysis, we wanted to explore the specific role of linc-UBC1 in malignant tumours by integrating all...

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Bibliographic Details
Published in:Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2020-01, Vol.48 (1), p.875-884
Main Authors: Zhang, Xiewu, Xie, Haibiao, Luo, Manjun, Liang, Daqiang, Lao, Weihua, Ma, Weijun, Lin, Yankun
Format: Article
Language:English
Subjects:
Biomarkers
Cancer
Cases (containers)
Gene expression
Gene Expression Regulation, Neoplastic
Humans
Linc-UBC1
LNM
Lymph nodes
Meta-analysis
Metastases
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - pathology
Overall survival
Phenotype
Phenotypes
Prognosis
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
systematic review and meta-analysis
TNM
Tumors
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Summary:According to previous studies, linc-UBC1 is abnormally expressed in various human tumours. Nonetheless, the clinical significance and mechanism of linc-UBC1 in cancer remains unclear. In our present analysis, we wanted to explore the specific role of linc-UBC1 in malignant tumours by integrating all of the relevant literature and subsequently elucidating the relationship between linc-UBC1 expression level and clinical characteristics of cancers. An elaborate database search of PubMed, Embase, Wanfang Data, Web of Science, Ovid, Medline, Cochrane Library and PMC was carried out up to 8 August 2019. We further applied the pooled odds ratio (OR) and hazard ratio (HR) to evaluate OS. After filtering by strict criteria, 11 studies containing 1017 cases were included in this analysis. Our results implied that high expression of linc-UBC1 was obviously related to poor OS in cancer (HR =1.735, 95% 1.348-2.235, p 
ISSN:2169-1401
2169-141X
DOI:10.1080/21691401.2020.1770776