Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Mice

Berries of (chokeberry) are known to be a rich source of biologically active polyphenols. In the present study, the effects of seven anti-adipogenic polyphenolic phytochemicals isolated from methanol extract on adipogenic transcription factors were investigated. Amygdalin and prunasin were found to...

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Bibliographic Details
Published in:Nutrients 2018-11, Vol.10 (11), p.1734
Main Authors: Kim, Na-Hyun, Jegal, Jonghwan, Kim, Yun Na, Heo, Jeong-Doo, Rho, Jung-Rae, Yang, Min Hye, Jeong, Eun Ju
Format: Article
Language:English
Subjects:
3T3-L1 Cells
Adipocytes - physiology
Adipogenesis - drug effects
adipogenic transcription factor
Adipose Tissue - cytology
Adipose Tissue - metabolism
Animals
anti-adipogenesis
Aronia melanocarpa
Body Weight
Cholesterol, LDL - blood
Diet, High-Fat - adverse effects
diet-induced obesity
Insulin Resistance
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity - drug therapy
Obesity - etiology
Obesity - metabolism
Obesity - physiopathology
Photinia - chemistry
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
polyphenols
Polyphenols - pharmacology
Polyphenols - therapeutic use
Triglycerides - blood
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Summary:Berries of (chokeberry) are known to be a rich source of biologically active polyphenols. In the present study, the effects of seven anti-adipogenic polyphenolic phytochemicals isolated from methanol extract on adipogenic transcription factors were investigated. Amygdalin and prunasin were found to inhibit 3T3-L1 adipocyte differentiation by suppressing the expressions of PPARγ (peroxisome proliferator-activated receptor γ), C/EBPα (CCAAT/enhancer binding protein α), SREBP1c (sterol regulatory element binding protein 1c), FAS (fatty acid synthase), and aP2 (adipocyte fatty-acid⁻binding protein). extract-treated (100 or 200 mg/kg/day on body weight) high fat diet (HFD)-induced obese mice showed significant decreases in body weight, serum triglyceride (TG), and low-density lipoprotein cholesterol (LDLC) levels and improved insulin sensitivity as compared with HFD controls. This research shows extract is potentially beneficial for the suppression of HFD-induced obesity.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu10111734