Sex difference in the associations among risk factors with gastroesophageal reflux disease in a large Taiwanese population study

• Published in: BMC gastroenterology 2024-05, Vol.24 (1), p.165-165, Article 165
• Main Authors: Lin, Chien-Chieh, Geng, Jiun-Hung, Wu, Pei-Yu, Huang, Jiun-Chi, Hu, Huang-Ming, Chen, Szu-Chia, Kuo, Chao-Hung
• Format: Article
• Language: English
• Subjects: Adult; Age; Age Factors; Aged; Alcohol; Alcohol Drinking - epidemiology; Blood Glucose - analysis; Blood pressure; Body mass index; Cholesterol; Chronic illnesses; Demographic aspects; Dextrose; Diabetes mellitus; Diabetes Mellitus - epidemiology; Diagnosis; Disease; Esophagus; Fasting; Female; Females; Gastroesophageal reflux; Gastroesophageal Reflux - epidemiology; Gastroesophageal reflux disease; Gender differences; Glomerular filtration rate; Glucose; Glycosylated hemoglobin; Health aspects; Hemoglobin; High density lipoprotein; Humans; Hypertension; Hypertension - epidemiology; Low density lipoproteins; Male; Males; Medical research; Medicine, Experimental; Middle Aged; Population studies; Prevalence; Public health; Regression analysis; Review boards; Risk Factors; Sex difference; Sex differences; Sex Factors; Smoking; Smoking - epidemiology; Statistical analysis; Surveys; Taiwan - epidemiology; Taiwan Biobank; Triglycerides; Uric acid; Uric Acid - blood; World health
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-024-03254-3

Gastroesophageal reflux disease (GERD) is a common global health issue. Previous studies have revealed a higher prevalence of GERD in females than in males, however few studies have investigated sex differences in the risk factors associated with GERD. Therefore, the aim of this population-based study was to examine sex differences in the risk factors for GERD in a large cohort of over 120,000 Taiwanese participants. We enrolled 121,583 participants (male: 43,698; female: 77,885; mean age 49.9 ± 11.0 years) from the Taiwan Biobank. The presence of GERD was ascertained using self-reported questionnaires. Sex differences in the risk factors associated with GERD were examined using multivariable logistic regression analysis. The overall prevalence of GERD was 13.7%, including 13.0% in the male participants and 14.1% in the female participants (p