A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest

• Published in: Scientific reports 2021-06, Vol.11 (1), p.12380-9, Article 12380
• Main Authors: Wang, Chih-Hung, Wu, Cheng-Yi, Wu, Meng-Che, Chang, Wei-Tien, Huang, Chien-Hua, Tsai, Min-Shan, Lu, Tsung-Chien, Chou, Eric, Hsieh, Yu-Lin, Chen, Wen-Jone
• Format: Article
• Language: English
• Subjects: 692/4019; 692/700; Aged; Blood; Cardiac arrest; Cardiopulmonary resuscitation; Cardiopulmonary Resuscitation - methods; CPR; Female; Heart; Heart Arrest - drug therapy; Humanities and Social Sciences; Humans; Inpatients - statistics & numerical data; Male; Middle Aged; multidisciplinary; pH effects; Regression analysis; Science; Science (multidisciplinary); Sodium; Sodium bicarbonate; Sodium Bicarbonate - administration & dosage; Sodium Bicarbonate - adverse effects; Sodium Bicarbonate - therapeutic use; Treatment Outcome
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-91936-3

To investigate whether the effects of sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR) would be influenced by blood pH and administration timing. Adult patients experiencing in-hospital cardiac arrest (IHCA) from 2006 to 2015 were retrospectively screened. Early intra-arrest blood gas data were obtained within 10 min of CPR. Multivariable logistic regression analysis and generalised additive models were used for effect estimation and data exploration, respectively. A total of 1060 patients were included. Only 59 patients demonstrated favourable neurological status at hospital discharge. Blood pH ≤ 7.18 was inversely associated with favourable neurological outcome (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.11–0.52; p value  7.18; OR 1.56; 95% CI 1.01–2.41; p value = 0.05). SB should not be empirically administered for patients with IHCA since its effects may be influenced by blood pH and administration timing.