Antiradical activity of Paulownia tomentosa (Scrophulariaceae) extracts

Paulownia tomentosa is a large indecidous tree planted mostly for its fast growing wood and decorative purposes. The tree is also used in traditional Chinese medicine. As a part of our study of natural polyphenols, the fruits of Paulownia tomentosa were extracted by EtOH and than subjected to liquid...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2007-06, Vol.12 (6), p.1210-1219
Main Authors: Smejkal, Karel, Holubova, Pavla, Zima, Ales, Muselik, Jan, Dvorska, Margita
Format: Article
Language:English
Subjects:
antioxidant
antiperoxynitrite
DPPH
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Flavonoids
Flavonoids - isolation & purification
Flavonoids - pharmacology
Free Radical Scavengers - isolation & purification
Free Radical Scavengers - pharmacology
Free radicals
Fruit - chemistry
Paulownia tomentosa
Pharmaceutical sciences
Pharmacy
phenolics
Phenols - isolation & purification
Phenols - pharmacology
Plants, Medicinal
Polyphenols
Solvents
Trees
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Summary:Paulownia tomentosa is a large indecidous tree planted mostly for its fast growing wood and decorative purposes. The tree is also used in traditional Chinese medicine. As a part of our study of natural polyphenols, the fruits of Paulownia tomentosa were extracted by EtOH and than subjected to liquid/liquid extraction. Fractions were analysed by TLC and HPLC to determine presence of phenolic substances. We identified and quantified acteoside (1) and isoacteoside (2) in the EtOAc and n-BuOH extracts; mimulone (3) and diplacone (4) in the MeOH extract. To determine the antiradical activity of extracts we used the anti DPPH and peroxynitrite assays. The activity was expressed as Trolox C equivalents, IC50 for DPPH scavenging and a time dependency course was established. The polyphenols content was determined; results were expressed as gallic acid equivalents. Using these methods we found the fractions of the n-BuOH, EtOAc and MeOH extracts that display antiradical activity, which could be exploited as potential pharmaceuticals.
ISSN:1420-3049
1420-3049
DOI:10.3390/12061210