The therapeutic effects of low-intensity pulsed ultrasound in musculoskeletal soft tissue injuries: Focusing on the molecular mechanism

Musculoskeletal soft tissue injuries are very common and usually occur during both sporting and everyday activities. The intervention of adjuvant therapies to promote tissue regeneration is of great importance to improving people's quality of life and extending their productive lives. Though ma...

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Bibliographic Details
Published in:Frontiers in bioengineering and biotechnology 2022-12, Vol.10, p.1080430-1080430
Main Authors: Qin, Haocheng, Du, Liang, Luo, Zhiwen, He, Zhong, Wang, Qing, Chen, Shiyi, Zhu, Yu-Lian
Format: Article
Language:English
Subjects:
Bioengineering and Biotechnology
inflammation
low-intensity pulsed ultrasound
mechanism
musculoskeletal injuries
regeneration
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Summary:Musculoskeletal soft tissue injuries are very common and usually occur during both sporting and everyday activities. The intervention of adjuvant therapies to promote tissue regeneration is of great importance to improving people's quality of life and extending their productive lives. Though many studies have focused on the positive results and effectiveness of the LIPUS on soft tissue, the molecular mechanisms standing behind LIPUS effects are much less explored and reported, especially the intracellular signaling pathways. We incorporated all research on LIPUS in soft tissue diseases since 2005 and summarized studies that uncovered the intracellular molecular mechanism. This review will also provide the latest evidence-based research progress in this field and suggest research directions for future experiments.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.1080430