Effects of resistant starch interventions on circulating inflammatory biomarkers: a systematic review and meta-analysis of randomized controlled trials

• Published in: Nutrition journal 2020-04, Vol.19 (1), p.33-33, Article 33
• Main Authors: Vahdat, Mahsa, Hosseini, Seyed Ahmad, Khalatbari Mohseni, Golsa, Heshmati, Javad, Rahimlou, Mehran
• Format: Article
• Language: English
• Subjects: Analysis; Bias; Biological markers; Biomarkers; C-reactive protein; CRP; Cytokines; Database industry; Diet; Disease; Fatty acids; Inflammation; Interleukin 6; Interleukins; Intervention; Meta-analysis; Metabolism; Proteins; Quality; Resistant starch; Review; Sensitivity analysis; Serum levels; Starch; Systematic review; TNF-α, IL-6; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Type 2 diabetes
• ISSN: 1475-2891; 1475-2891
• DOI: 10.1186/s12937-020-00548-6

This study aimed to summarize earlier studies on the effects of RS consumption on the serum levels of inflammatory biomarkers. A comprehensive search was done in the electronic databases that published from 1988 up to May 2019. Two reviewers independently performed screening, data extraction, and risk-of-bias assessment. We used from the effect size, as estimated by the mean difference to perform the fixed method meta-analysis. Overall, 13 studies with 14 effect sizes met the inclusion criteria and were included in the final analysis. Sample size of these studies ranged from 15 to 75 and intervention duration ranged from 4 to 14 weeks. Meta-analysis revealed that higher consumption of resistant starch caused a significant reduction in the interleukin 6 (weighted mean difference = - 1.11 pg/mL; 95% CI: - 1.72, - 0.5 pg/mL; P =