Circulating GLP-1 Levels in Patients with Pheochromocytoma/Paraganglioma

The sympathoadrenal system has been shown to stimulate the secretory activity of enteroendocrine cells, although the response is transient. Our aim was to investigate the effects of long-term catecholamine excess on circulating glucagon-likepeptide-1 (GLP-1) levels in patients with pheochromocytoma/...

Full description

Saved in:
Bibliographic Details
Published in:International journal of endocrinology 2022-12, Vol.2022, p.4203018-7
Main Authors: Chen, Nan, Chen, Yan, Lai, Fenghua, Chen, Li, Zeng, Rui, Pei, Ling, Wu, Liting, Wang, Chenxue, Li, Yanbing, Xiao, Haipeng, Cao, Xiaopei
Format: Article
Language:English
Subjects:
Body mass index
Care and treatment
Catecholamines
Correlation analysis
Creatinine
Dextrose
Diabetes
Endocrinology
Glucagon
Glucose
Health aspects
High density lipoprotein
Hormones
Hyperglycemia
Hypertension
Insulin resistance
Laboratories
Localization
Metabolic disorders
Metabolites
Neuroendocrine tumors
Plasma
Risk factors
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The sympathoadrenal system has been shown to stimulate the secretory activity of enteroendocrine cells, although the response is transient. Our aim was to investigate the effects of long-term catecholamine excess on circulating glucagon-likepeptide-1 (GLP-1) levels in patients with pheochromocytoma/paraganglioma (PPGL). Thirty patients diagnosed with PPGL were analyzed. A significant negative association was observed between fasting plasma GLP-1 levels and elevated plasma-free metanephrine (r=−0.407,p=0.026). After adjustment for age, sex, body mass index (BMI), serum creatinine, and the presence of hyperglycemia, the negative association between plasma GLP-1 and metanephrine persisted by multiple linear regression analysis (β=−0.493,p=0.013). Positive correlations between fasting glucose and plasma metanephrine (r=0.380,p=0.038) and normetanephrine levels (r=0.450,p=0.013) were also found. Mean fasting levels of total GLP-1 increased significantly from 25.81 to 39.01 pmol/L (p=0.017) after PPGL resection. In conclusion, long-term overproduction of catecholamines appears to induce suppression of GLP-1 production compared to an acute response to a stress stimulus. Further studies are required to elucidate the mechanism of GLP-1 secretion with chronic exposure to catecholamine.
ISSN:1687-8337
1687-8345
DOI:10.1155/2022/4203018