In Situ Monitoring of Drug Precipitation from Digesting Lipid Formulations Using Low-Frequency Raman Scattering Spectroscopy

Low-frequency Raman spectroscopy (LFRS) is a valuable tool to detect the solid state of amorphous and crystalline drugs in solid dosage forms and the transformation of drugs between different polymorphic forms. It has also been applied to track the solubilisation of solid drugs as suspensions in mil...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2023-07, Vol.15 (7), p.1968
Main Authors: Salim, Malinda, Fraser-Miller, Sara J, Bērziņš, Kārlis, Sutton, Joshua J, Gordon, Keith C, Boyd, Ben J
Format: Article
Language:English
Subjects:
Analysis
Caffeine
Chloride
Discriminant analysis
drug
Drug delivery systems
Drugs
Fenofibrate
in vitro digestion
Information management
lipid-based formulation
Lipids
low-frequency Raman spectroscopy
Pharmaceuticals
Polymer solubility
precipitation
Principal components analysis
Raman spectroscopy
SNEDDS
Software
Spectrum analysis
Surfactants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Low-frequency Raman spectroscopy (LFRS) is a valuable tool to detect the solid state of amorphous and crystalline drugs in solid dosage forms and the transformation of drugs between different polymorphic forms. It has also been applied to track the solubilisation of solid drugs as suspensions in milk and infant formula during in vitro digestion. This study reports the use of LFRS as an approach to probe drug precipitation from a lipid-based drug delivery system (medium-chain self-nanoemulsifying drug delivery system, MC-SNEDDS) during in vitro digestion. Upon lipolysis of the digestible components in MC-SNEDDS containing fenofibrate as a model drug, sharp phonon peaks appeared at the low-frequency Raman spectral region (
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15071968