The usefulness of noninvasive liver stiffness assessment using shear-wave elastography for predicting liver fibrosis in children

Pediatric patients with liver disease require noninvasive monitoring to evaluate the risk of fibrosis progression. This study aimed to identify the significant factors affecting liver stiffness values using two-dimensional shear-wave elastography (2D-SWE), and determine whether liver stiffness can p...

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Bibliographic Details
Published in:BMC medical imaging 2021-04, Vol.21 (1), p.68-10, Article 68
Main Authors: Lee, Seunghyun, Choi, Young Hun, Cho, Yeon Jin, Lee, Seul Bi, Cheon, Jung-Eun, Kim, Woo Sun, Ko, Jae Sung, Koh, Jaemoon, Kang, Gyeong Hoon
Format: Article
Language:English
Subjects:
Adolescent
Alanine
Alanine transaminase
Alanine Transaminase - blood
Biopsy
Child
Child, Preschool
Children
Diagnostic systems
Diseases
Elasticity
Elasticity imaging techniques
Elasticity Imaging Techniques - methods
Female
Fibrosis
Hepatitis
Humans
Infant
Infant, Newborn
Liver
Liver - diagnostic imaging
Liver - enzymology
Liver - pathology
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - enzymology
Liver Cirrhosis - pathology
Liver diseases
Male
Metabolism
Original Research
Patients
Pediatrics
Performance evaluation
Regression Analysis
ROC Curve
Serology
Steatosis
Stiffness
Transaminase
Two dimensional analysis
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Summary:Pediatric patients with liver disease require noninvasive monitoring to evaluate the risk of fibrosis progression. This study aimed to identify the significant factors affecting liver stiffness values using two-dimensional shear-wave elastography (2D-SWE), and determine whether liver stiffness can predict the fibrosis stage of various childhood liver diseases. This study included 30 children (22 boys and 8 girls; mean age, 5.1 ± 6.1 years; range, 7 days-17.9 years) who had undergone biochemical evaluation, 2D-SWE examination, histopathologic analysis of fibrosis grade (F0 to F3), assessment of necroinflammatory activity, and steatosis grading between August 2016 and March 2020. The liver stiffness from 2D-SWE was compared between fibrosis stages using Kruskal-Wallis analysis. Factors that significantly affected liver stiffness were evaluated using univariate and multivariate linear regression analyses. The diagnostic performance was determined from the area under the receiver operating curve (AUC) values of 2D-SWE liver stiffness. Liver stiffness at the F0-1, F2, and F3 stages were 7.9, 13.2, and 21.7 kPa, respectively (P 
ISSN:1471-2342
1471-2342
DOI:10.1186/s12880-021-00601-8