A Symbiotic Meal Containing Extruded Sorghum and Probiotic ( Bifidobacterium longum ) Ameliorated Intestinal Health Markers in Individuals with Chronic Kidney Disease: A Secondary Analysis of a Subsample from a Previous Randomized and Controlled Clinical Trial

• Published in: Nutrients 2024-06, Vol.16 (12), p.1852
• Main Authors: Lúcio, Haira Guedes, Lopes, Rita de Cassia Stampini Oliveira, Gomes, Mariana Juste Contin, da Silva, Alessandra, Grancieri, Mariana, Della Lucia, Ceres Mattos, Queiroz, Valéria Aparecida Vieira, da Silva, Bárbara Pereira, Martino, Hercia Stampini Duarte
• Format: Article
• Language: English
• Subjects: Adult; Aged; Bacteria; Bifidobacterium longum; Biomarkers - blood; Carbohydrates; Clinical trials; Constipation; Dietary fiber; Dysbiosis; Fatty Acids, Volatile - analysis; Fatty Acids, Volatile - metabolism; Female; Gastrointestinal Microbiome - drug effects; gut microbiota; Hemodialysis; Hospitals; Humans; Inflammation; Intestines - microbiology; Kidney diseases; Lactose; Lactose intolerance; Male; Microbiota; Microorganisms; Middle Aged; Milk; Nephrology; Permeability; Probiotics; Probiotics - administration & dosage; Renal Insufficiency, Chronic - therapy; SCFAs; Single-Blind Method; Sociodemographics; Sorghum; Sorghum bicolor L. Moench; symbiotic meal; Toxins; uremic toxins
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16121852

Chronic kidney disease increases uremic toxins concentrations, which have been associated with intestinal dysbiosis. L. Moench has dietary fiber and bioactive compounds, while can promote beneficial health effects. It is a controlled, randomized, and single-blind clinical trial. Thirty-nine subjects were randomly separated into two groups: symbiotic group (SG), which received 100 mL of unfermented probiotic milk with strain and 40 g of extruded sorghum flakes; and the control group (CG), which received 100 mL of pasteurized milk and 40 g of extruded corn flakes for seven weeks. The uremic toxins decreased, and gastrointestinal symptoms improved intragroup in the SG group. The acetic, propionic, and butyric acid production increased intragroup in the SG group. Regarding α-diversity, the Chao1 index was enhanced in the SG intragroup. The KEGG analysis revealed that symbiotic meal increased the intragroup energy and amino sugar metabolism, in addition to enabling essential amino acid production and metabolism, sucrose degradation, and the biosynthesis of ribonucleotide metabolic pathways. The consumption of symbiotic meal reduced BMI, improved short-chain fatty acid (SCFA) synthesis and gastrointestinal symptoms, increased diversity according to the Chao1 index, and reduced uremic toxins in chronic kidney disease patients.