Whole genome sequence analysis of NDM-1, CMY-4, and SHV-12 coproducing Salmonella enterica serovar Typhimurium isolated from a case of fatal burn wound infection

• Published in: Infection and drug resistance 2018, Vol.11, p.2491-2495
• Main Authors: Banerjee, Kokila, Sekar, Priyadharshini, Krishnan, Padma, Wattam, Alice Rebecca, Roy, Subhendu, Hays, John P, Menezes, Godfred A
• Format: Article
• Language: English
• Subjects: Antibiotics; Bacteria; Beta lactamases; Burns; Carbapenems; Case Report; Cefepime; co-production; Complications and side effects; Development and progression; Diarrhea; DNA sequencing; Drug resistance; Drug therapy; EDTA; Extended spectrum and AmpC β-lactamase; fatal burn wound; Gastrointestinal diseases; Genetic aspects; Genomes; Genomics; Hospitals; Imipenem; Infection; Infections; Laboratories; Metallo- β-lactamase; Microbial drug resistance; Nucleotide sequence; Nursing homes; Public health; Salmonella; Salmonella enterica; Salmonella typhimurium; Salmonellosis; Sulbactam; Tazobactam; Tetracyclines; Tigecycline; whole genome sequencing; Wound infection
• ISSN: 1178-6973; 1178-6973
• DOI: 10.2147/IDR.S167027

species are frequently associated with gastrointestinal infections such as diarrhea. However, extraintestinal infections, including burn infections, have been described. Here, we report the first case of a carbapenem-resistant and metallo-β-lactamase (New Delhi metallo-β-lactamase), extended-spectrum β-lactamase (SHV-12), and AmpC β-lactamase (CMY-4) coproducing Typhimurium isolated from a fatal case of burn wound infection. The publication highlights the necessity for the rational use of antibiotics (particularly the rational use of last-resort antibiotics such as carbapenems) in hospitals and burn units, as well as the need for systematic screening of spp. (including serovar Typhimurium) for resistance to carbapenem antibiotics.