F-ATP synthase inhibitory factor 1 and mitochondria-organelle interactions: New insight and implications

• Published in: Pharmacological research 2024-10, Vol.208, p.107393, Article 107393
• Main Author: Guo, Lishu
• Format: Article
• Language: English
• Subjects: Animals; ATPase Inhibitory Protein; Ca2; Calcium - metabolism; F-ATP synthase inhibitory factor 1; Humans; Metabolites; Mitochondria; Mitochondria - metabolism; Mitochondria-organelle interactions; Mitochondrial Permeability Transition Pore - metabolism; Permeability transition; Reactive Oxygen Species - metabolism; ROS
• ISSN: 1043-6618; 1096-1186; 1096-1186
• DOI: 10.1016/j.phrs.2024.107393

Mitochondria are metabolic hub, and act as primary sites for reactive oxygen species (ROS) and metabolites generation. Mitochondrial Ca2+ uptake contributes to Ca2+ storage. Mitochondria-organelle interactions are important for cellular metabolic adaptation, biosynthesis, redox balance, cell fate. Organelle communications are mediated by Ca2+/ROS signals, vesicle transport and membrane contact sites. The permeability transition pore (PTP) is an unselective channel that provides a release pathway for Ca2+/ROS, mtDNA and metabolites. F-ATP synthase inhibitory factor 1 (IF1) participates in regulation of PTP opening and is required for the translocation of transcriptional factors c-Myc/PGC1α to mitochondria to stimulate metabolic switch. IF1, a mitochondrial specific protein, has been suggested to regulate other organelles including nucleus, endoplasmic reticulum and lysosomes. IF1 may be able to mediate mitochondria-organelle interactions and cellular physiology through regulation of PTP activity. [Display omitted]