Polyphenols from Brown Seaweeds (Ochrophyta, Phaeophyceae): Phlorotannins in the Pursuit of Natural Alternatives to Tackle Neurodegeneration

Globally, the burden of neurodegenerative disorders continues to rise, and their multifactorial etiology has been regarded as among the most challenging medical issues. Bioprospecting for seaweed-derived multimodal acting products has earned increasing attention in the fight against neurodegenerativ...

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Bibliographic Details
Published in:Marine drugs 2020-12, Vol.18 (12), p.654
Main Authors: Barbosa, Mariana, Valentão, Patrícia, Andrade, Paula B
Format: Article
Language:English
Subjects:
Aetiology
Algae
Animals
Antioxidants
Apoptosis
Aβ amyloid
Biodiversity
Biological Products - isolation & purification
Biological Products - therapeutic use
Bioprospecting
Brain research
Cognitive ability
Disease
Drug therapy
Enzymes
Etiology
Humans
Hypotheses
Metabolites
multitarget
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - drug therapy
neuroinflammation
Neurological disorders
Neuropathology
Neuroprotection
Neuroprotective Agents - isolation & purification
Neuroprotective Agents - therapeutic use
Neurotoxicity
Oxidative stress
Phaeophyceae - chemistry
Phloroglucinol
phlorotannins
Polyphenols
Polyphenols - isolation & purification
Polyphenols - therapeutic use
Proteins
R&D
Research & development
Review
Seaweed - chemistry
Seaweeds
Tannins - isolation & purification
Tannins - therapeutic use
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Summary:Globally, the burden of neurodegenerative disorders continues to rise, and their multifactorial etiology has been regarded as among the most challenging medical issues. Bioprospecting for seaweed-derived multimodal acting products has earned increasing attention in the fight against neurodegenerative conditions. Phlorotannins (phloroglucinol-based polyphenols exclusively produced by brown seaweeds) are amongst the most promising nature-sourced compounds in terms of functionality, and though research on their neuroprotective properties is still in its infancy, phlorotannins have been found to modulate intricate events within the neuronal network. This review comprehensively covers the available literature on the neuroprotective potential of both isolated phlorotannins and phlorotannin-rich extracts/fractions, highlighting the main key findings and pointing to some potential directions for neuro research ramp-up processes on these marine-derived products.
ISSN:1660-3397
1660-3397
DOI:10.3390/md18120654