Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved]

Introduction: Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. Methods: In this cross-sectional study, we examined how cognitive decline and hippocampal subfields vol...

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Bibliographic Details
Published in:F1000 research 2022, Vol.11, p.114-114
Main Authors: Cucos, Catalina Anca, Cracana, Ioana, Dobre, Maria, Popescu, Bogdan Ovidiu, Tudose, Catalina, Spiru, Luiza, Manda, Gina, Niculescu, Gabriela, Milanesi, Elena
Format: Article
Language:English
Subjects:
blood
Cognitive decline
eng
MRI
SRXN1
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Summary:Introduction: Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. Methods: In this cross-sectional study, we examined how cognitive decline and hippocampal subfields volume are associated with the expression of redox and inflammatory genes in peripheral blood. We analyzed 34 individuals with different cognitive scores according to Mini-Mental State Examination, corrected by age and education (adjMMSE). We identified a group presenting cognitive decline (CD) with adjMMSE
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.76191.2