Urinary microRNA in Diabetic Kidney Disease: A Literature Review

Diabetic kidney disease is the most common primary disease of end-stage kidney disease globally; however, a sensitive and accurate biomarker to predict this disease remains awaited. microRNAs are endogenous single-stranded noncoding RNAs that have intervened in different post-transcriptional regulat...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2023-02, Vol.59 (2), p.354
Main Authors: Lee, Chin-Chan, Chen, Chia-Chun, Hsu, Cheng-Kai, Chen, Yih-Ting, Chen, Chun-Yu, Yang, Kai-Jie, Hung, Ming-Jui, Wu, I-Wen
Format: Article
Language:English
Subjects:
Analysis
Biomarkers
Development and progression
Diabetes
diabetes mellitus
Diabetes Mellitus - pathology
diabetic kidney disease
Diabetic nephropathies
Diabetic Nephropathies - metabolism
Diabetic nephropathy
Diagnosis
exosomes
Gene Expression
Gene Expression Regulation
Genetic aspects
Health aspects
Homeostasis
Humans
Kidney - pathology
Kidney diseases
Literature reviews
Measurement
MicroRNA
MicroRNAs
MicroRNAs - genetics
Pathophysiology
Proteins
Review
RNA polymerase
urinary
Urine
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Summary:Diabetic kidney disease is the most common primary disease of end-stage kidney disease globally; however, a sensitive and accurate biomarker to predict this disease remains awaited. microRNAs are endogenous single-stranded noncoding RNAs that have intervened in different post-transcriptional regulations of various cellular biological functions. Previous literatures have reported its potential role in the pathophysiology of diabetic kidney disease, including regulation of Transforming Growth Factor-β1-mediated fibrosis, extracellular matrix and cell adhesion proteins, cellular hypertrophy, growth factor, cytokine production, and redox system activation. Urinary microRNAs have emerged as a novel, non-invasive liquid biopsy for disease diagnosis. In this review, we describe the available experimental and clinical evidence of urinary microRNA in the context of diabetic kidney disease and discuss the future application of microRNA in routine practice.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59020354