Chlamydia trachomatis transmission between the oropharynx, urethra and anorectum in men who have sex with men: a mathematical model

It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal...

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Published in:BMC medicine 2020-11, Vol.18 (1), p.326-10, Article 326
Main Authors: Xu, Xianglong, Chow, Eric P F, Ong, Jason J, Hoebe, Christian J P A, Zou, Zhuoru, Hocking, Jane S, Fairley, Christopher K, Zhang, Lei
Format: Article
Language:English
Subjects:
Anal sex
Anatomical site
Behavioural interventions
Calibration
Chlamydia
Chlamydia infections
Chlamydia Infections - transmission
Chlamydia trachomatis
Chlamydia trachomatis - pathogenicity
Condoms
Contamination
Demographic aspects
Diagnosis
Disease transmission
Distribution
Gays & lesbians
Health aspects
Health care facilities
Homosexuality, Male
Humans
Infections
Male
Mathematical analysis
Mathematical models
Men
Men who have sex with men
Mens health
Models, Theoretical
MSM (Men who have sex with men)
Ordinary differential equations
Oropharynx
Oropharynx - virology
Penis
Rectal Diseases - virology
Rectum
Saliva
Sexual practices
Sexually transmitted diseases
STD
Transmission
Urethra
Urethra - virology
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Zhang, Lei
description It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal sex and calibrated these models to the observed rates of Chlamydia trachomatis infection at three anatomical sites from 4888 men who have sex with men (MSM) in Melbourne Sexual Health Centre during 2018-2019. A model that included only oral and anal sex could replicate the observed rates of single-site infection at the oropharynx, urethra and rectum alone, but could not replicate infection at more than one of these sites (multisite). However, if we included transmission from sexual practices that followed one another in the same sexual episode (e.g. saliva contamination of the penis from oral sex transmitting chlamydia to the rectum by anal sex), we significantly improved the calibration of multisite infection rates substantially. Our modelling study suggests that transmission routes other than just oral and anal sex are necessary to explain the high rate of Chlamydia trachomatis infection at more than one site.
doi_str_mv 10.1186/s12916-020-01796-3
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subjects Anal sex
Anatomical site
Behavioural interventions
Calibration
Chlamydia
Chlamydia infections
Chlamydia Infections - transmission
Chlamydia trachomatis
Chlamydia trachomatis - pathogenicity
Condoms
Contamination
Demographic aspects
Diagnosis
Disease transmission
Distribution
Gays & lesbians
Health aspects
Health care facilities
Homosexuality, Male
Humans
Infections
Male
Mathematical analysis
Mathematical models
Men
Men who have sex with men
Mens health
Models, Theoretical
MSM (Men who have sex with men)
Ordinary differential equations
Oropharynx
Oropharynx - virology
Penis
Rectal Diseases - virology
Rectum
Saliva
Sexual practices
Sexually transmitted diseases
STD
Transmission
Urethra
Urethra - virology
title Chlamydia trachomatis transmission between the oropharynx, urethra and anorectum in men who have sex with men: a mathematical model
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