BMP13 prevents the effects of annular injury in an ovine model

Chronic back pain is a global health problem affecting millions of people worldwide and carries significant economic and social morbidities. Intervertebral disc damage and degeneration is a major cause of back pain, characterised by histological and biochemical changes that have been well documented...

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Bibliographic Details
Published in:International journal of biological sciences 2009-01, Vol.5 (5), p.388-396
Main Authors: Wei, Aiqun, Williams, Lisa A, Bhargav, Divya, Shen, Bojiang, Kishen, Thomas, Duffy, Neil, Diwan, Ashish D
Format: Article
Language:English
Subjects:
Animals
Collagen - biosynthesis
Disease Models, Animal
Growth Differentiation Factor 6 - therapeutic use
Humans
Immunohistochemistry
Injections, Intra-Articular
Lumbar Vertebrae - diagnostic imaging
Lumbar Vertebrae - pathology
Magnetic Resonance Imaging
Male
Pilot Projects
Proteoglycans - biosynthesis
Radiography
Recombinant Proteins - therapeutic use
Sheep
Short Research Communication
Spinal Diseases - diagnostic imaging
Spinal Diseases - pathology
Spinal Diseases - prevention & control
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Summary:Chronic back pain is a global health problem affecting millions of people worldwide and carries significant economic and social morbidities. Intervertebral disc damage and degeneration is a major cause of back pain, characterised by histological and biochemical changes that have been well documented in animal models. Recently there has been intense interest in early intervention in disc degeneration using growth factors or stem cell transplantation, to replenish the diseased tissues. Bone Morphogenetic Proteins (BMPs) have been approved for clinical use in augmenting spinal fusions, and may represent candidate molecules for intervertebral disc regeneration. BMP13 has an important role in embryonic development and recent genetic evidence shows a role in the development of the human spine. This study explores the effect of BMP13 on a damaged intervertebral disc in an ovine model of discal degeneration. We found that, when injected at the time of injury, BMP13 reversed or arrested histological changes that occurred in the control discs such as loss of extracellular matrix proteins. In addition, BMP13 injected discs retained greater hydration after 4 months, and possessed more cells in the NP. Taken together, BMP13 may be a potent clinical therapeutic agent when used early in the degeneration cascade to promote healthy disc tissue.
ISSN:1449-2288
1449-2288
DOI:10.7150/ijbs.5.388