Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo

Ultrafine resveratrol (u-Res) particles were prepared through the SAS process. The orthogonal method was used to optimize the factors of the SAS process. The size of u-Res reached 0.68 μm under the optimum conditions. The characterization of the u-Res particles was tested by many analysis methods. T...

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Bibliographic Details
Published in:Advances in materials science and engineering 2015-01, Vol.2015 (2015), p.1-10
Main Authors: Yu, Xinyang, Zhang, Xiaonan, Li, Jialei, Zu, Yuangang, Zhao, Xiuhua, Wang, Kunlun, Sun, Wei
Format: Article
Language:English
Subjects:
Atoms & subatomic particles
Bioavailability
Ethanol
Free radicals
Heat exchangers
Molecular weight
Natural gas utilities
Particle size
Stainless steel
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Summary:Ultrafine resveratrol (u-Res) particles were prepared through the SAS process. The orthogonal method was used to optimize the factors of the SAS process. The size of u-Res reached 0.68 μm under the optimum conditions. The characterization of the u-Res particles was tested by many analysis methods. The chemical structure of Res was unaffected by the SAS process. The degree of crystallinity of the u-Res particles greatly reduced. The purity of the u-Res particles increased from 98.5% to 99.2% during the SAS process. The u-Res particles had greater saturation solubility and dissolution rate than the raw-Res (r-Res) particles. The radical scavenging activity and bioavailability of the u-Res in vivo were 1.9 times of the r-Res.
ISSN:1687-8434
1687-8442
DOI:10.1155/2015/838513