Association of Plasminogen Activator Inhibitor-1 (PAI-1) Gene Polymorphisms with Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women

Osteoporosis and osteoporotic fractures are strongly associated with mortality and morbidity, both in developing and developed countries. Menopause accelerates bone loss due to estrogen deficiency and age-related linear bone loss. We investigated plasminogen activator inhibitor-1 ( ) gene polymorphi...

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Published in:International journal of molecular sciences 2016-12, Vol.17 (12), p.2062-2062
Main Authors: Kim, Jung Oh, Han, Soo Hong, Lee, Yeon Ho, Ahn, Tae Keun, Lim, Jae Joon, Chung, Young Sun, Shin, Dong Eun, Lee, Woo Sik, Han, In Bo, Kim, Nam Keun
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Case-Control Studies
Female
Fractures
Fractures, Compression - genetics
Fractures, Compression - pathology
Genetic Predisposition to Disease - genetics
Genotype
Haplotypes - genetics
Humans
Middle Aged
Osteoporosis
Osteoporosis - genetics
Osteoporosis - pathology
osteoporotic vertebral compression fractures
PAI-1
Plasminogen Activator Inhibitor 1 - genetics
plasminogen activator inhibitor-1
Polymorphism
Polymorphism, Genetic - genetics
Postmenopause
Women
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Summary:Osteoporosis and osteoporotic fractures are strongly associated with mortality and morbidity, both in developing and developed countries. Menopause accelerates bone loss due to estrogen deficiency and age-related linear bone loss. We investigated plasminogen activator inhibitor-1 ( ) gene polymorphisms in postmenopausal women with osteoporotic vertebral compression fractures (OVCFs). In this case-control study, 355 postmenopausal women were genotyped for the presence of gene polymorphisms -844A > G, -675 4G > 5G, 43G > A, 9785A > G, and 11053T > G. Genetic polymorphisms of were analyzed by the polymerization chain reaction restriction fragment length polymorphism assay, and their association with disease status and folate and homocysteine levels was determined in 158 OVCF patients and 197 control subjects. The -675 5G5G (adjusted odds ratio (AOR), 3.302; 0.017) and 43GA + AA (AOR, 2.087; 0.042) genotype frequencies showed significant association with the increased prevalence of OVCFs in postmenopausal women. In addition, we performed gene-environment interaction studies and demonstrated an association between gene polymorphisms and OVCF prevalence. Our novel finding is the identification of several genetic variants that increase susceptibility to OVCF. Our findings suggest that polymorphisms in may contribute to OVCF, and that they can be developed as biomarkers for evaluating OVCF risk.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17122062