Coenzyme Q10 Supplementation in Athletes: A Systematic Review

Background: To summarize available evidence in the literature on the impacts of CoQ10 supplementation on metabolic, biochemical, and performance outcomes in athletes. Methods: Six databases, Cochrane Library (33 articles), PubMed (90 articles), Scopus (55 articles), Embase (60 articles), SPORTDiscus...

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Published in:Nutrients 2023-09, Vol.15 (18), p.3990
Main Authors: Fernandes, Matheus Santos de Sousa, Fidelis, Débora Eduarda da Silvia, Aidar, Felipe J, Badicu, Georgian, Greco, Gianpiero, Cataldi, Stefania, Santos, Gabriela Carvalho Jurema, de Souza, Raphael Frabrício, Ardigò, Luca Paolo
Format: Article
Language:English
Subjects:
Antioxidants
Athletes
Body composition
Body fat
Body mass index
Chronic illnesses
Creatinine
Dietary supplements
Enzymes
Exercise
Kinases
Liver diseases
Oxidation
Oxidative stress
physical activity
Physical fitness
physical training
Review
sports nutrition
Student athletes
Systematic review
Type 2 diabetes
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Summary:Background: To summarize available evidence in the literature on the impacts of CoQ10 supplementation on metabolic, biochemical, and performance outcomes in athletes. Methods: Six databases, Cochrane Library (33 articles), PubMed (90 articles), Scopus (55 articles), Embase (60 articles), SPORTDiscus (1056 articles), and Science Direct (165 articles), were researched. After applying the eligibility criteria, articles were selected for peer review independently as they were identified by June 2022. The protocol for this systematic review was registered on PROSPERO (CRD42022357750). Results: Of the 1409 articles found, 16 were selected for this systematic review. After CoQ10 supplementation, a decrease in oxidative stress markers was observed, followed by higher antioxidant activity. On the other hand, lower levels of liver damage markers (ALT); Aspartate aminotransferase (AST); and Gamma-glutamyl transpeptidase (γGT) were identified. Finally, we found a reduction in fatigue indicators such as Creatine Kinase (CK) and an increase in anaerobic performance. Conclusions: This systematic review concludes that supplementation with orally administered CoQ10 (30–300 mg) was able to potentiate plasma antioxidant activity and anaerobic performance, reducing markers linked to oxidative stress and liver damage in athletes from different modalities aged 17 years old and older.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15183990