Immune-enhancing Effects of Chitosan-fermented Feed Additive on Broiler Chickens and Subsequent Protection Conferred against Experimental Infection with Salmonella Gallinarum

Benefits chitosan-fermented feed additives (CFFAs) particularly in the regulation of the immune system and antimicrobial activity. Therefore, we investigated the immune-enhancing and bacterial clearance effects of CFFA (fermented by Bacillus licheniformis) on broiler chickens Salmonella Gallinarum c...

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Bibliographic Details
Published in:The Journal of Poultry Science 2023, Vol.60(2), pp.2023016
Main Authors: Park, Bo Mi, Lee, Jina, Park, Young Kyu, Yang, Young Cheol, Jung, Bock Gie, Lee, Bong Joo
Format: Article
Language:English
Subjects:
Antimicrobial activity
Bacteria
broilers
Chickens
Chitosan
Experimental infection
Feed additives
fermentation
Food additives
Immune clearance
Immune response
Immune system
Immunology
insect
Lymphocytes
Lysozyme
Poultry
Salmonella
Salmonella Gallinarum
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Summary:Benefits chitosan-fermented feed additives (CFFAs) particularly in the regulation of the immune system and antimicrobial activity. Therefore, we investigated the immune-enhancing and bacterial clearance effects of CFFA (fermented by Bacillus licheniformis) on broiler chickens Salmonella Gallinarum challenge. We administered 2% or 4% CFFA evaluated its immune-enhancing effects using several immunological experiments, including examination of lysozyme activity, lymphocyte proliferation, and expression of cytokines. We also evaluated the bacterial clearance effects of CFFA against S. Gallinarum. CFFA administration markedly enhanced lysozyme activity, lymphocyte proliferation, and the expression of interleukin (IL)-2, IL-12, tumor necrosis factor alpha, and interferon gamma in the spleen. In broilers challenged with S. Gallinarum, the clinical signs of S. Gallinarum infection and the number of viable bacterial colonies in the feces and tissues decreased in both CFFA groups. Therefore, CFFAs could be good candidates for feed additive to improve nonspecific immune responses and bacterial clearance.
ISSN:1346-7395
1349-0486
DOI:10.2141/jpsa.2023016