Sugar content and erosive potential of commonly prescribed Orodispersible tablets- An in vitro study. [version 2; peer review: 2 approved]

Background: Dental caries is a major non-communicable disease of public health concern caused due to freely available dietary sugars. We aimed to compare the sugar content and erosive potential with duration of use and drug classes of orodispersible tablets (ODTs).  Methods: We conducted an  in vitr...

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Bibliographic Details
Published in:F1000 research 2023, Vol.12, p.228
Main Authors: Anand, Lahari, Pentapati, Kalyana, Shenoy, Revathi, Yelleti, Geethika, Kumar, Saurabh
Format: Article
Language:English
Subjects:
Acidity
Acids
Antiemetics
Antimicrobial agents
Dental caries
Dispersible tablets
Drug dosages
eng
Erosive potential
Laboratories
Oral
pH effects
Phenolphthalein
Phenols
Proton pump inhibitors
Public health
Sodium hydroxide
Solubility
Sugar
Sugar content
Sulfuric acid
Tablets
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Summary:Background: Dental caries is a major non-communicable disease of public health concern caused due to freely available dietary sugars. We aimed to compare the sugar content and erosive potential with duration of use and drug classes of orodispersible tablets (ODTs).  Methods: We conducted an  in vitro evaluation of the total sugar content (TSC), Potential of Hydrogen (pH), solubility, and Titratable Acidity (TA) of commonly prescribed 62 ODTs. TA was measured by titrating the samples with known amount of. 0.1N sodium hydroxide (NaOH) with phenolphthalein indicator and pH was determined by digital pH meter. TSC was evaluated by phenol sulphuric acid. Solubility was assessed by filtration.  Results: Out of the 62 ODTs, majority were Antimicrobials (n=30). One-quarter of the ODTs (26%) had a mean pH below ≤5.5. No significant difference was seen in the mean pH with respect to different drug classes (p=0.082) and duration of use of ODTs. A significant difference was seen in the mean percentage solubility with respect to drug classes (p
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.130786.2