Chlorahololide D, a Lindenane-Type Sesquiterpenoid Dimer from Chloranthus holostegius Suppressing Breast Cancer Progression

Aimed at discovering small molecules as anticancer drugs or lead compounds from plants, a lindenane-type sesquiterpene dimer, chlorahololide D, was isolated from Chloranthus holostegius. The literature review showed that there were few reports on the antitumor effects and mechanisms of chlorahololid...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-10, Vol.28 (20), p.7070
Main Authors: Li, Ying, Liu, Wenhui, Xu, Jing, Guo, Yuanqiang
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Cancer therapies
Cell cycle
Chemotherapy
Chloranthus holostegius
Cytotoxicity
Drug dosages
Embryos
FAK
Flow cytometry
Herbal medicine
lindenane-type sesquiterpenoid dimer
Medical research
Metastasis
Natural products
Proteins
Reactive oxygen species
Software
Tumors
zebrafish model
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Summary:Aimed at discovering small molecules as anticancer drugs or lead compounds from plants, a lindenane-type sesquiterpene dimer, chlorahololide D, was isolated from Chloranthus holostegius. The literature review showed that there were few reports on the antitumor effects and mechanisms of chlorahololide D. Our biological assay suggested that chlorahololide D blocked the growth and triggered apoptosis of MCF-7 cells by stimulating the reactive oxygen species (ROS) levels and arresting the cell cycle at the G2 stage. Further mechanism exploration suggested that chlorahololide D regulated apoptosis-related proteins Bcl-2 and Bax. Moreover, chlorahololide D inhibited cell migration by regulating the FAK signaling pathway. In the zebrafish xenograft model, chlorahololide D was observed to suppress tumor proliferation and migration significantly. Considering the crucial function of angiogenesis in tumor development, the anti-angiogenesis of chlorahololide D was also investigated. All of the research preliminarily revealed that chlorahololide D could become an anti-breast cancer drug.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28207070