Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia

Abstract Abnormal coagulation properties indicative of a dysfibrinogenemia were found in the plasma of an asymptomatic 65-year-old male. An immunoglobulin k light chain was found to interfere with Fg functional assay and coagulation tests (activated partial thromboplastin time, prothrombin time, and...

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Bibliographic Details
Published in:TH open : companion journal to thrombosis and haemostasis 2019-01, Vol.3 (1), p.e64-e66
Main Authors: Martini, Francesca, Cecconi, Nadia, Paolicchi, Aldo, Galimberti, Sara, Cervetti, Giulia, Buda, Gabriele, Petrini, Mario
Format: Article
Language:English
Subjects:
Case Report
coagulation factors
fibrin
fibrinogen
inhibitor
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Summary:Abstract Abnormal coagulation properties indicative of a dysfibrinogenemia were found in the plasma of an asymptomatic 65-year-old male. An immunoglobulin k light chain was found to interfere with Fg functional assay and coagulation tests (activated partial thromboplastin time, prothrombin time, and thrombin time). Steroid therapy reduced the inhibitory effect (after dexamethasone treatment coagulation test and functional Fg value normalized). Spurious dysfibrinogenemia associated with light chain monoclonal gammopathy of undetermined significance was diagnosed.
ISSN:2512-9465
2567-3459
2512-9465
DOI:10.1055/s-0039-1683969