Novel Substituted Thiophenes and Sulf-Polyacetylene Ester from Echinops ritro L

Three new substituted bithiophenes ( ⁻ ), and one new sulf-polyacetylene ester, ritroyne A ( ) were isolated from the whole plant of together with twelve known substituted thiophenes. The structures were elucidated on the basis of extensive spectroscopic analysis including 1D and 2D NMR as well as M...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-02, Vol.24 (4), p.805
Main Authors: Li, Liang-Bo, Xiao, Guang-Da, Xiang, Wei, Yang, Xing, Cao, Ke-Xin, Huang, Rong-Shao
Format: Article
Language:English
Subjects:
Absolute configuration
Aldehydes
antimicrobial activities
Antimicrobial agents
Carbon
Carboxylic acids
Echinops ritro
Natural products
Planar structures
Polyacetylene
sulf-polyacetylene
Thiophenes
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Summary:Three new substituted bithiophenes ( ⁻ ), and one new sulf-polyacetylene ester, ritroyne A ( ) were isolated from the whole plant of together with twelve known substituted thiophenes. The structures were elucidated on the basis of extensive spectroscopic analysis including 1D and 2D NMR as well as MS. Furthermore, the absolute configuration of ritroyne A ( ) was established by computational methods. In bioscreening experiments, four compounds ( , , , ) showed similar antibacterial activity against ATCC 2592 with levofloxacin (8 µg/mL). Five compounds ( , , , , ) exhibited antibacterial activities against ATCC 25922, with minimum inhibitory concentration (MIC) values of 32⁻64 µg/mL. Three compounds ( , , ) exhibited antifungal activities against ATCC 2002 with MIC values of 32⁻64 µg/mL. However, compound did not exhibit antimicrobial activities against three microorganisms.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24040805