Association of SLIT3 and ZNF280B Gene Polymorphisms with Wool Fiber Diameter

The SLIT3 gene encodes a secreted protein, and the ZNF280B gene is a member of the transcription factor family. Both genes have multiple biological functions. This study was conducted to investigate the association between SLIT3 and ZNF280B gene polymorphisms and wool fiber diameter and to determine...

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Bibliographic Details
Published in:Animals (Basel) 2023-11, Vol.13 (22), p.3552
Main Authors: Yue, Lin, Lu, Zengkui, Guo, Tingting, Liu, Jianbin, Yuan, Chao, Yang, Bohui
Format: Article
Language:English
Subjects:
Alpine Merino sheep
Angiogenesis
Animals
Annealing
association analysis
Biotechnology
Cell growth
fiber diameter
Fibroblasts
Genes
Genomes
Growth factors
Keratin
Localization
Prostate cancer
Sheep
Skin
SLIT3
Textiles
Wool
ZNF280B
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Summary:The SLIT3 gene encodes a secreted protein, and the ZNF280B gene is a member of the transcription factor family. Both genes have multiple biological functions. This study was conducted to investigate the association between SLIT3 and ZNF280B gene polymorphisms and wool fiber diameter and to determine potential molecular marker sites for breeding sheep with fine wool. We used Kompetitive Allele-Specific PCR to type the single nucleotide polymorphism (SNP) loci in the SLIT3 and ZNF280B genes within 1081 Alpine Merino sheep and associated these SNPs with wool fiber diameter. The results revealed one SNP in SLIT3 and ZNF280B, which were each related to sheep fiber diameter. The wool fiber diameters of sheep with the CC genotype in SLIT3 g.478807C>G and AA genotype in ZNF280B g.677G>A were the smallest and differed significantly from the diameters of other genotypes (p < 0.05). These results suggest potential molecular marker sites for fine-wool sheep breeding.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani13223552