Use of Hydrogels to Regulate Orthodontic Tooth Movement in Animal Models: A Systematic Review

The objective of this article is to conduct a systematic review of the literature to contrast the existing evidence regarding the use of hydrogels during and after experimental orthodontic treatment in animals. An extensive search was performed through the electronic databases, Medline, Web of Scien...

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Bibliographic Details
Published in:Applied sciences 2022-07, Vol.12 (13), p.6683
Main Authors: Montero Jiménez, Olin Guadalupe, Dib Kanán, Alejandro, Dipp Velázquez, Farid Alfonso, Aristizábal Pérez, Juan Fernando, Moyaho Bernal, María de los Ángeles, Salas Orozco, Marco Felipe, Casillas Santana, Miguel Angel
Format: Article
Language:English
Subjects:
acceleration
Animal models
Animals
Bias
Bisphosphonates
Boolean
Cancer therapies
Evaluation
Experimentation
Guinea pigs
Hydrogels
In vivo methods and tests
Literature reviews
orthodontic tooth movement
Orthodontics
Polyethylene glycol
Quality assessment
Quality control
Rabbits
relapse
Systematic review
Teeth
Vehicles
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Summary:The objective of this article is to conduct a systematic review of the literature to contrast the existing evidence regarding the use of hydrogels during and after experimental orthodontic treatment in animals. An extensive search was performed through the electronic databases, Medline, Web of Science and Scopus, from December 2020 to April 2021 for in vivo animal studies. A total of 282 studies were reviewed. Eight studies were included for final revision; four studies were conducted in rats, two in rabbits, one study in mice and one study in guinea pigs. The quality assessment of the eight included studies was performed according to the ARRIVE guidelines and the risk of bias was assessed using the Center for Systematic Review of Laboratory Animal Experimentation tool; in four of the eight articles evaluated, a high risk-of-bias rating was obtained in 40% of the criteria evaluated. In the studies reviewed, the hydrogel acted as a carrier, and inhibition (post-treatment retention) or acceleration of orthodontic tooth movement was assessed according to the active substance used in each of the articles. The uses of hydrogels for transporting active substances to regulate the rate of orthodontic tooth movement remains debatable. Future studies are suggested to evaluate the feasibility of hydrogel as a transport method in humans.
ISSN:2076-3417
2076-3417
DOI:10.3390/app12136683