Target and candidate agents for diabetes treatment in the framework of the food nexus

• Published in: Energy nexus 2022-03, Vol.5, p.100041, Article 100041
• Main Authors: Abirami, Dhandapani, Gomathi, R.
• Format: Article
• Language: English
• Subjects: Pharmacodynamics; Pharmacokinetics; Tecoma stans; Thioredoxin-interacting protein; Toxicological profiles and phytochemical compounds
• ISSN: 2772-4271; 2772-4271
• DOI: 10.1016/j.nexus.2022.100041

•Diabetes mellitus is a chronic disease due to less production of insulin.•Phytochemical constituents of Tecoma stans interacts with thioredoxin interacting protein thioredoxin-interacting protein.•Six phytochemicals present in the Tecoma stans showed good binding attraction to the binding pocket of thioredoxin-interacting protein.•pkCSM server was used to detect pharmacodynamics, pharmacokinetics and toxicological profiles of phytochemical compounds.•The amino acids Lysin 117, Lysin 115 and Glycine 119 acted as the key residues to inhibit thioredoxin-interacting protein. Diabetes mellitus is a chronic disease affected by scarcity in the production of insulin. In the present study, we used the bioinformatics approach to examine the possible inhibitory abilities of phytochemical constituents of Tecoma stans towards thioredoxin interacting protein. All the phytochemicals showed good binding attraction to the binding pocket of thioredoxin-interacting protein. pkCSM server was used to detect pharmacodynamics, pharmacokinetics and toxicological profiles of phytochemical compounds. The amino acids Lysin 117, Lysin 115 and Glycine 119 were exhibited as the key residues for the phytochemicals of Tecoma stans and binding to inhibit the thioredoxin-interacting protein. However further studies are needed to identify the efficacies and activities of Tecoma stans compounds against thioredoxin-interacting protein. [Display omitted]