Loading…
Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans
Animal behavior is directed by the integration of sensory information from internal states and the environment. Neuroendocrine regulation of diverse behaviors of is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. Here, we show that males exhibit an altered, male-sp...
Saved in:
| Published in: | eLife 2017-01, Vol.6 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c5336-dcb92654aab1058f3f30e9bfeba8cd3504e8d43755a937cc453bda060aeabf73 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c5336-dcb92654aab1058f3f30e9bfeba8cd3504e8d43755a937cc453bda060aeabf73 |
| container_end_page | |
| container_issue | |
| container_start_page | |
| container_title | eLife |
| container_volume | 6 |
| creator | Hilbert, Zoë A Kim, Dennis H |
| description | Animal behavior is directed by the integration of sensory information from internal states and the environment. Neuroendocrine regulation of diverse behaviors of
is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. Here, we show that
males exhibit an altered, male-specific expression pattern of
in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. Molecular genetic analysis of the switch-like regulation of
expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in
. |
| doi_str_mv | 10.7554/eLife.21166 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_8e52cd2f49434087adb5aa414b49325a</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478729464</galeid><doaj_id>oai_doaj_org_article_8e52cd2f49434087adb5aa414b49325a</doaj_id><sourcerecordid>A478729464</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5336-dcb92654aab1058f3f30e9bfeba8cd3504e8d43755a937cc453bda060aeabf73</originalsourceid><addsrcrecordid>eNptks1v2yAYxq1p01plPe0-Ie2yaUoGBvxxmVRF-4gUadLaw27oNX7tkNmQgl0l__1w0nXNNDiA4Pc-wMOTJK8ZXeRSio-4Ng0uUsay7FlymVJJ57QQP58_mV8kVyFsaWy5KApWvkwu0oKxPMvYZXJ3g_sRuu5AatM7v9sYTbSzg3cdcQ1p0SLB_c5jCMZZYiwJaIPzB2Jx9M4G4rEdOxgwkBq1mah5D7-MbUmFG7g3zk9VywXBDluw4VXyooEu4NXDOEtuv3y-XX6br79_XS2v13MtOc_mta7KNJMCoGJUFg1vOMWyarCCQtdcUoFFLXg0AUqeay0kr2qgGQWEqsn5LFmdZGsHW7Xzpgd_UA6MOi443yrwg9EdqgJlquu0EaXgghY51JUEEExUouSphKj16aS1G6sea43RH-jORM93rNmo1t0rmWYpz6fLvHsQ8O5uxDCo3gSNXQcW3RgUKzKWMUbjBWbJ23_QrRu9jU4pVkpOy5zl5V-qhfgAYxsXz9WTqLoWeZGnpcgmrcV_qNhr7E38ZWxMXD8reH9WMCUB90MLYwhqdfPjnP1wYrV3IXhsHv1gVE3ZVMdsqmM2I_3mqYWP7J8k8t-xlt-q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1953097179</pqid></control><display><type>article</type><title>Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>PubMed Central</source><creator>Hilbert, Zoë A ; Kim, Dennis H</creator><creatorcontrib>Hilbert, Zoë A ; Kim, Dennis H</creatorcontrib><description>Animal behavior is directed by the integration of sensory information from internal states and the environment. Neuroendocrine regulation of diverse behaviors of
is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. Here, we show that
males exhibit an altered, male-specific expression pattern of
in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. Molecular genetic analysis of the switch-like regulation of
expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in
.</description><identifier>ISSN: 2050-084X</identifier><identifier>EISSN: 2050-084X</identifier><identifier>DOI: 10.7554/eLife.21166</identifier><identifier>PMID: 28117661</identifier><language>eng</language><publisher>England: eLife Science Publications, Ltd</publisher><subject>Animals ; Bacteria ; Behavior ; Behavior, Animal ; Caenorhabditis elegans ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - physiology ; Caenorhabditis elegans Proteins - metabolism ; Clinical decision making ; daf-7 ; Decision Making ; Dimorphism (Biology) ; E coli ; Experiments ; Female ; Gene expression ; Gene Expression Regulation ; Genetic analysis ; Genetic aspects ; Male ; Males ; Morphology ; Nervous system ; Neural circuitry ; Neuroendocrine system ; Neurons ; Neuroscience ; Nutritional status ; Observations ; Pseudomonas aeruginosa ; Sensory integration ; Sensory neurons ; Sensory Receptor Cells - physiology ; Sensory receptors ; Sexual dimorphism ; Transforming Growth Factor beta - metabolism</subject><ispartof>eLife, 2017-01, Vol.6</ispartof><rights>COPYRIGHT 2017 eLife Science Publications, Ltd.</rights><rights>2017, Hilbert et al. This work is licensed under the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/3.0/ ) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017, Hilbert et al 2017 Hilbert et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5336-dcb92654aab1058f3f30e9bfeba8cd3504e8d43755a937cc453bda060aeabf73</citedby><cites>FETCH-LOGICAL-c5336-dcb92654aab1058f3f30e9bfeba8cd3504e8d43755a937cc453bda060aeabf73</cites><orcidid>0000-0002-3833-6912 ; 0000-0002-4109-5152</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1953097179/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1953097179?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28117661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hilbert, Zoë A</creatorcontrib><creatorcontrib>Kim, Dennis H</creatorcontrib><title>Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans</title><title>eLife</title><addtitle>Elife</addtitle><description>Animal behavior is directed by the integration of sensory information from internal states and the environment. Neuroendocrine regulation of diverse behaviors of
is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. Here, we show that
males exhibit an altered, male-specific expression pattern of
in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. Molecular genetic analysis of the switch-like regulation of
expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in
.</description><subject>Animals</subject><subject>Bacteria</subject><subject>Behavior</subject><subject>Behavior, Animal</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - physiology</subject><subject>Caenorhabditis elegans Proteins - metabolism</subject><subject>Clinical decision making</subject><subject>daf-7</subject><subject>Decision Making</subject><subject>Dimorphism (Biology)</subject><subject>E coli</subject><subject>Experiments</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Genetic analysis</subject><subject>Genetic aspects</subject><subject>Male</subject><subject>Males</subject><subject>Morphology</subject><subject>Nervous system</subject><subject>Neural circuitry</subject><subject>Neuroendocrine system</subject><subject>Neurons</subject><subject>Neuroscience</subject><subject>Nutritional status</subject><subject>Observations</subject><subject>Pseudomonas aeruginosa</subject><subject>Sensory integration</subject><subject>Sensory neurons</subject><subject>Sensory Receptor Cells - physiology</subject><subject>Sensory receptors</subject><subject>Sexual dimorphism</subject><subject>Transforming Growth Factor beta - metabolism</subject><issn>2050-084X</issn><issn>2050-084X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptks1v2yAYxq1p01plPe0-Ie2yaUoGBvxxmVRF-4gUadLaw27oNX7tkNmQgl0l__1w0nXNNDiA4Pc-wMOTJK8ZXeRSio-4Ng0uUsay7FlymVJJ57QQP58_mV8kVyFsaWy5KApWvkwu0oKxPMvYZXJ3g_sRuu5AatM7v9sYTbSzg3cdcQ1p0SLB_c5jCMZZYiwJaIPzB2Jx9M4G4rEdOxgwkBq1mah5D7-MbUmFG7g3zk9VywXBDluw4VXyooEu4NXDOEtuv3y-XX6br79_XS2v13MtOc_mta7KNJMCoGJUFg1vOMWyarCCQtdcUoFFLXg0AUqeay0kr2qgGQWEqsn5LFmdZGsHW7Xzpgd_UA6MOi443yrwg9EdqgJlquu0EaXgghY51JUEEExUouSphKj16aS1G6sea43RH-jORM93rNmo1t0rmWYpz6fLvHsQ8O5uxDCo3gSNXQcW3RgUKzKWMUbjBWbJ23_QrRu9jU4pVkpOy5zl5V-qhfgAYxsXz9WTqLoWeZGnpcgmrcV_qNhr7E38ZWxMXD8reH9WMCUB90MLYwhqdfPjnP1wYrV3IXhsHv1gVE3ZVMdsqmM2I_3mqYWP7J8k8t-xlt-q</recordid><startdate>20170124</startdate><enddate>20170124</enddate><creator>Hilbert, Zoë A</creator><creator>Kim, Dennis H</creator><general>eLife Science Publications, Ltd</general><general>eLife Sciences Publications Ltd</general><general>eLife Sciences Publications, Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3833-6912</orcidid><orcidid>https://orcid.org/0000-0002-4109-5152</orcidid></search><sort><creationdate>20170124</creationdate><title>Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans</title><author>Hilbert, Zoë A ; Kim, Dennis H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5336-dcb92654aab1058f3f30e9bfeba8cd3504e8d43755a937cc453bda060aeabf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Bacteria</topic><topic>Behavior</topic><topic>Behavior, Animal</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans - physiology</topic><topic>Caenorhabditis elegans Proteins - metabolism</topic><topic>Clinical decision making</topic><topic>daf-7</topic><topic>Decision Making</topic><topic>Dimorphism (Biology)</topic><topic>E coli</topic><topic>Experiments</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Genetic analysis</topic><topic>Genetic aspects</topic><topic>Male</topic><topic>Males</topic><topic>Morphology</topic><topic>Nervous system</topic><topic>Neural circuitry</topic><topic>Neuroendocrine system</topic><topic>Neurons</topic><topic>Neuroscience</topic><topic>Nutritional status</topic><topic>Observations</topic><topic>Pseudomonas aeruginosa</topic><topic>Sensory integration</topic><topic>Sensory neurons</topic><topic>Sensory Receptor Cells - physiology</topic><topic>Sensory receptors</topic><topic>Sexual dimorphism</topic><topic>Transforming Growth Factor beta - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hilbert, Zoë A</creatorcontrib><creatorcontrib>Kim, Dennis H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>eLife</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hilbert, Zoë A</au><au>Kim, Dennis H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans</atitle><jtitle>eLife</jtitle><addtitle>Elife</addtitle><date>2017-01-24</date><risdate>2017</risdate><volume>6</volume><issn>2050-084X</issn><eissn>2050-084X</eissn><abstract>Animal behavior is directed by the integration of sensory information from internal states and the environment. Neuroendocrine regulation of diverse behaviors of
is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. Here, we show that
males exhibit an altered, male-specific expression pattern of
in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. Molecular genetic analysis of the switch-like regulation of
expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in
.</abstract><cop>England</cop><pub>eLife Science Publications, Ltd</pub><pmid>28117661</pmid><doi>10.7554/eLife.21166</doi><orcidid>https://orcid.org/0000-0002-3833-6912</orcidid><orcidid>https://orcid.org/0000-0002-4109-5152</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2050-084X |
| ispartof | eLife, 2017-01, Vol.6 |
| issn | 2050-084X 2050-084X |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_8e52cd2f49434087adb5aa414b49325a |
| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central |
| subjects | Animals Bacteria Behavior Behavior, Animal Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - metabolism Clinical decision making daf-7 Decision Making Dimorphism (Biology) E coli Experiments Female Gene expression Gene Expression Regulation Genetic analysis Genetic aspects Male Males Morphology Nervous system Neural circuitry Neuroendocrine system Neurons Neuroscience Nutritional status Observations Pseudomonas aeruginosa Sensory integration Sensory neurons Sensory Receptor Cells - physiology Sensory receptors Sexual dimorphism Transforming Growth Factor beta - metabolism |
| title | Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T11%3A07%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sexually%20dimorphic%20control%20of%20gene%20expression%20in%20sensory%20neurons%20regulates%20decision-making%20behavior%20in%20C.%20elegans&rft.jtitle=eLife&rft.au=Hilbert,%20Zo%C3%AB%20A&rft.date=2017-01-24&rft.volume=6&rft.issn=2050-084X&rft.eissn=2050-084X&rft_id=info:doi/10.7554/eLife.21166&rft_dat=%3Cgale_doaj_%3EA478729464%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5336-dcb92654aab1058f3f30e9bfeba8cd3504e8d43755a937cc453bda060aeabf73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1953097179&rft_id=info:pmid/28117661&rft_galeid=A478729464&rfr_iscdi=true |