Synuclein Proteins in Cancer Development and Progression

Synucleins are a family of small, soluble proteins mainly expressed in neural tissue and in certain tumors. Since their discovery, tens of thousands of scientific reports have been published about this family of proteins as they are associated with severe human diseases. Although the physiological f...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-06, Vol.13 (6), p.980
Main Authors: Zanotti, Lucía C, Malizia, Florencia, Cesatti Laluce, Nahuel, Avila, Aylén, Mamberto, Macarena, Anselmino, Luciano E, Menacho-Márquez, Mauricio
Format: Article
Language:English
Subjects:
aggregation
Alzheimer's disease
Amino acids
biomarkers
Brain
Breast cancer
Cancer
Cellular proteins
Development and progression
Health aspects
Lipids
Membranes
Neurodegeneration
Oncology, Experimental
pathways
Physiological aspects
Physiology
Proteins
Review
Synuclein
synucleins
Vertebrates
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Summary:Synucleins are a family of small, soluble proteins mainly expressed in neural tissue and in certain tumors. Since their discovery, tens of thousands of scientific reports have been published about this family of proteins as they are associated with severe human diseases. Although the physiological function of these proteins is still elusive, their relationship with neurodegeneration and cancer has been clearly described over the years. In this review, we summarize data connecting synucleins and cancer, going from the structural description of these molecules to their involvement in tumor-related processes, and discuss the putative use of these proteins as cancer molecular biomarkers.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13060980