Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumor regression in mice. Nanoparticles were injected intra-tumorally in melanoma-bearing C57BL/6J mice and were subjected to radiofreque...

Full description

Saved in:
Bibliographic Details
Published in:International journal of nanomedicine 2016-01, Vol.11 (default), p.1779-1791
Main Authors: Haghniaz, Reihaneh, Umrani, Rinku D, Paknikar, Kishore M
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Apoptosis - drug effects
Caspase 3 - metabolism
Caspases - metabolism
Cell Proliferation - drug effects
Dextrans - chemistry
DNA Fragmentation
heat shock proteins
Heat-Shock Proteins - metabolism
HSP70 Heat-Shock Proteins - metabolism
hyperthermia
Hyperthermia, Induced
In Situ Nick-End Labeling
Inflammation - pathology
Lanthanum - chemistry
lanthanum strontium manganese oxide nanoparticles
Magnetic Resonance Imaging
Manganese Compounds - chemistry
melanoma
Melanoma, Experimental - pathology
Melanoma, Experimental - therapy
Mice, Inbred C57BL
MRI
Nanoparticles - chemistry
Original Research
Oxides - chemistry
Strontium - chemistry
survival
Tissue Distribution - drug effects
tumor regression
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumor regression in mice. Nanoparticles were injected intra-tumorally in melanoma-bearing C57BL/6J mice and were subjected to radiofrequency treatment. Hyperthermia treatment significantly inhibited tumor growth (~84%), increased survival (~50%), and reduced tumor proliferation in mice. Histopathological examination demonstrated immense cell death in treated tumors. DNA fragmentation, increased terminal deoxynucleotidyl transferase-dUTP nick end labeling signal, and elevated levels of caspase-3 and caspase-6 suggested apoptotic cell death. Enhanced catalase activity suggested reactive oxygen species-mediated cell death. Enhanced expression of heat shock proteins 70 and 90 in treated tumors suggested the possible development of "antitumor immunity". The dextran-coated lanthanum strontium manganese oxide-mediated hyperthermia can be used for the treatment of cancer.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S104617