Roles of LonP1 in Oral-Maxillofacial Developmental Defects and Tumors: A Novel Insight

Recent studies have indicated a central role for LonP1 in mitochondrial function. Its physiological functions include proteolysis, acting as a molecular chaperone, binding mitochondrial DNA, and being involved in cellular respiration, cellular metabolism, and oxidative stress. Given its vital role i...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-11, Vol.23 (21), p.13370
Main Authors: Ma, Haozhen, Chen, Wanting, Fan, Wenguo, He, Hongwen, Huang, Fang
Format: Article
Language:English
Subjects:
Abnormalities
Adenosine triphosphate
E coli
Energy metabolism
Etiology
Hypoxia
LonP1
Maxillofacial
Metabolism
Microscopy
Mitochondrial DNA
mitochondrial Lon protease
molecular chaperone
Molecular modelling
Mutation
Neoplasms
oral and maxillofacial oncology
Oral cancer
Oxidative metabolism
Oxidative stress
Peptides
Phenotypes
Physiology
Proteins
Proteolysis
Review
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent studies have indicated a central role for LonP1 in mitochondrial function. Its physiological functions include proteolysis, acting as a molecular chaperone, binding mitochondrial DNA, and being involved in cellular respiration, cellular metabolism, and oxidative stress. Given its vital role in energy metabolism, LonP1 has been suggested to be associated with multi-system neoplasms and developmental disorders. In this study, we investigated the roles, possible mechanisms of action, and therapeutic roles of LonP1 in oral and maxillofacial tumor development. LonP1 was highly expressed in oral-maxillofacial cancers and regulated their development through a sig-naling network. LonP1 may therefore be a promising anticancer therapy target. Mutations in LONP1 have been found to be involved in the etiology of cerebral, ocular, dental, auricular, and skeletal syndrome (CODAS). Only patients carrying specific LONP1 mutations have certain dental abnormalities (delayed eruption and abnormal morphology). LonP1 is therefore a novel factor in the development of oral and maxillofacial tumors. Greater research should therefore be conducted on the diagnosis and therapy of LonP1-related diseases to further define LonP1-associated oral phenotypes and their underlying molecular mechanisms.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232113370