Liver X Receptor–Binding DNA Motif Associated With Atherosclerosis‐Specific DNA Methylation Profiles of Alu Elements and Neighboring CpG Islands

Background The signals that determine atherosclerosis‐specific DNA methylation profiles are only partially known. We previously identified a 29‐bp DNA motif (differential methylation motif [DMM]) proximal to CpG islands (CGIs) that undergo demethylation in advanced human atheromas. Those data hinted...

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Bibliographic Details
Published in:Journal of the American Heart Association 2018-02, Vol.7 (3), p.n/a
Main Authors: Tristán‐Flores, Fabiola E., Guzmán, Plinio, Ortega‐Kermedy, Melany S., Cruz‐Torres, Gabriela, Rocha, Carmen, Silva‐Martínez, Guillermo A., Rodríguez‐Ríos, Dalia, Alvarado‐Caudillo, Yolanda, Barbosa‐Sabanero, Gloria, Sayols, Sergi, Lund, Gertrud, Zaina, Silvio
Format: Article
Language:English
Subjects:
Alu Elements
atherosclerosis
Atherosclerosis - genetics
Atherosclerosis - metabolism
Benzoates - pharmacology
Benzylamines - pharmacology
Binding Sites
CpG Islands
DNA Methylation - drug effects
Epigenesis, Genetic - drug effects
epigenetics
Gene Expression Profiling
genomics
Humans
Liver X Receptors - agonists
Liver X Receptors - genetics
Liver X Receptors - metabolism
Nucleotide Motifs
Original Research
Protein Binding
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
THP-1 Cells
Two-Hybrid System Techniques
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Summary:Background The signals that determine atherosclerosis‐specific DNA methylation profiles are only partially known. We previously identified a 29‐bp DNA motif (differential methylation motif [DMM]) proximal to CpG islands (CGIs) that undergo demethylation in advanced human atheromas. Those data hinted that the DMM docks modifiers of DNA methylation and transcription. Methods and Results We sought to functionally characterize the DMM. We showed that the DMM overlaps with the RNA polymerase III–binding B box of Alu short interspersed nuclear elements and contains a DR2 nuclear receptor response element. Pointing to a possible functional role for an Alu DMM, CGIs proximal (
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.117.007686