Priapism following acute overdose of perphenazine: a case report

AbstractIschemic priapism is a rare event, but represents a medical emergency requiring aggressive treatment. While clinicians associate priapism with phosphodiesterase-5 (PDE-5) inhibitors, antipsychotics and α adrenergic antagonists represent a higher number of cases. We present the case of a 52-y...

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Bibliographic Details
Published in:Toxicology communications 2024-12, Vol.8 (1)
Main Authors: Perriello, Emily, Laskey, Dayne, Griswold, Matthew K
Format: Article
Language:English
Subjects:
antipsychotic
case report
overdose
Perphenazine
priapism
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Summary:AbstractIschemic priapism is a rare event, but represents a medical emergency requiring aggressive treatment. While clinicians associate priapism with phosphodiesterase-5 (PDE-5) inhibitors, antipsychotics and α adrenergic antagonists represent a higher number of cases. We present the case of a 52-year-old male who experienced an episode of ischemic priapism secondary to acute overdose of perphenazine. We were unable to locate any prior case of priapism associated with acute perphenazine overdose in the literature. When managing a patient with acute overdose of a first-generation antipsychotic with α-blocking effects such as perphenazine, clinicians should consider this uncommon but serious complication.
ISSN:2473-4306
2473-4306
DOI:10.1080/24734306.2024.2339074