Systematic Review of Binge Eating Rodent Models for Developing Novel or Repurposing Existing Pharmacotherapies

Recent advances in developing and screening candidate pharmacotherapies for psychiatric disorders have depended on rodent models. Eating disorders are a set of psychiatric disorders that have traditionally relied on behavioral therapies for effective long-term treatment. However, the clinical use of...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-04, Vol.13 (5), p.742
Main Authors: Berger, Gregory, Corris, Joshua D, Fields, Spencer E, Hao, Lihong, Scarpa, Lori L, Bello, Nicholas T
Format: Article
Language:English
Subjects:
Animal models
binge
Binge eating
Binge-Eating Disorder - diagnosis
Binge-Eating Disorder - drug therapy
Binge-Eating Disorder - psychology
Bulimia
Bulimia - diagnosis
Bulimia - psychology
Bulimia - therapy
Bulimia Nervosa - diagnosis
Bulimia Nervosa - psychology
Bulimia Nervosa - therapy
Cognitive Behavioral Therapy
Compulsive eating
Drug therapy
Eating behavior
Eating disorders
eating pathologies
FDA approval
fluoxetine
Humans
Hypotheses
Mental disorders
Performance evaluation
Pregnancy
Prozac
Psychotherapy
Psychotropic drugs
rat
Review
Systematic review
Testing
Vomiting
Vyvanse
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Summary:Recent advances in developing and screening candidate pharmacotherapies for psychiatric disorders have depended on rodent models. Eating disorders are a set of psychiatric disorders that have traditionally relied on behavioral therapies for effective long-term treatment. However, the clinical use of Lisdexamfatamine for binge eating disorder (BED) has furthered the notion of using pharmacotherapies for treating binge eating pathologies. While there are several binge eating rodent models, there is not a consensus on how to define pharmacological effectiveness within these models. Our purpose is to provide an overview of the potential pharmacotherapies or compounds tested in established rodent models of binge eating behavior. These findings will help provide guidance for determining pharmacological effectiveness for potential novel or repurposed pharmacotherapies.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13050742