Loading…

Proof-of-Principle of Absolute Dosimetry Using an Absorbed Dose Portable Calorimeter with Laser-Driven Proton Beams

Charged particle beams driven to ultra-high dose rates (UHDRs) have been shown to offer potential benefits for future clinical applications, particularly in the reduction of normal-tissue toxicity. Studies of the so-called FLASH effect have shown promise, generating huge interest in high dose rate r...

Full description

Saved in:
Bibliographic Details
Published in:Applied sciences 2023-11, Vol.13 (21), p.11894
Main Authors: McCallum, Sean, Lee, Nigel, Milluzzo, Giuliana, McIlvenny, Aodhan, Borghesi, Marco, Subiel, Anna, Romano, Francesco
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c406t-3c3e06d01a2cfcf883860842d29571cac5cde533d63ea2462394f583a8a61a2b3
cites cdi_FETCH-LOGICAL-c406t-3c3e06d01a2cfcf883860842d29571cac5cde533d63ea2462394f583a8a61a2b3
container_end_page
container_issue 21
container_start_page 11894
container_title Applied sciences
container_volume 13
creator McCallum, Sean
Lee, Nigel
Milluzzo, Giuliana
McIlvenny, Aodhan
Borghesi, Marco
Subiel, Anna
Romano, Francesco
description Charged particle beams driven to ultra-high dose rates (UHDRs) have been shown to offer potential benefits for future clinical applications, particularly in the reduction of normal-tissue toxicity. Studies of the so-called FLASH effect have shown promise, generating huge interest in high dose rate radiation studies. With laser-driven proton beams, where the duration of the proton burst delivered to a sample can be as short as hundreds of picoseconds, the instantaneous dose rates are several orders of magnitude higher than those used for conventional radiotherapy. The dosimetry of these beam modalities is not trivial, with conventional active detectors, such as ionisation chambers, experiencing saturation effects making them unusable at the extremely high dose rates. Calorimeters, measuring the radiation-induced temperature rise in an absorber, offer an ideal candidate for the dosimetry of UHDR beams. However, their application in the measurement of laser-driven UHDR beams has so far not been trialled, and their effective suitability to work with the quasi-instantaneous and inhomogeneous dose deposition patterns and the harsh environment of a laser-plasma experiment has not been tested. The measurement of the absorbed dose of laser-driven proton beams was conducted in a first-of-its-kind investigation, employing the VULCAN-PW laser system of the Central Laser Facility (CLF) at the Rutherford Appleton Laboratory (RAL), using a small-body portable graphite calorimeter (SPGC) developed at the National Physical Laboratory (NPL) and radiochromic films. A small number of shots were recorded, with the corresponding absorbed dose measurements resulting from the induced temperature rise. The effect of the electromagnetic pulse (EMP) generated during laser–target interaction was assessed on the system, showing no significant effects on the derived signal-to-noise ratio. These proof-of-principle tests highlight the ability of calorimetry techniques to measure the absorbed dose for laser-driven proton beams.
doi_str_mv 10.3390/app132111894
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_8eac82d6cf1e4d669e6f7b82cf1dea8e</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A772531330</galeid><doaj_id>oai_doaj_org_article_8eac82d6cf1e4d669e6f7b82cf1dea8e</doaj_id><sourcerecordid>A772531330</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-3c3e06d01a2cfcf883860842d29571cac5cde533d63ea2462394f583a8a61a2b3</originalsourceid><addsrcrecordid>eNpNUcFq3DAQNaGFhDS3fICg1zqVNLYsH7ebpg0sdA_NWYyl0UaL13Ilb0v-vtpsKRkEM8y89-ahqapbwe8Aev4Z51mAFELovrmoriTvVA2N6N69qS-rm5z3vEQvQAt-VeVtitHX5W1TmGyYR2LRs9WQ43hciN3HHA60pBf2lMO0Yzi9ztJA7jQjto1pwaGw1jjGdMJSYn_C8sw2mCnV9yn8pomVNUuc2BfCQ_5Qvfc4Zrr5l6-rp4evP9ff682Pb4_r1aa2DVdLDRaIK8cFSuut1xq04rqRTvZtJyza1jpqAZwCQtkoCX3jWw2oURXOANfV41nXRdybuZjD9GIiBvPaiGlnMC3BjmQ0odXSKesFNU6pnpTvBl0WC0eoqWh9PGvNKf46Ul7MPh7TVOwbqbUu365EX1B3Z9QOi2iYfFwSFqfo6BBsnMiH0l91nWxBAPBC-HQm2BRzTuT_2xTcnM5q3p4V_gL5ZpVC</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2888111619</pqid></control><display><type>article</type><title>Proof-of-Principle of Absolute Dosimetry Using an Absorbed Dose Portable Calorimeter with Laser-Driven Proton Beams</title><source>Publicly Available Content Database</source><creator>McCallum, Sean ; Lee, Nigel ; Milluzzo, Giuliana ; McIlvenny, Aodhan ; Borghesi, Marco ; Subiel, Anna ; Romano, Francesco</creator><creatorcontrib>McCallum, Sean ; Lee, Nigel ; Milluzzo, Giuliana ; McIlvenny, Aodhan ; Borghesi, Marco ; Subiel, Anna ; Romano, Francesco</creatorcontrib><description>Charged particle beams driven to ultra-high dose rates (UHDRs) have been shown to offer potential benefits for future clinical applications, particularly in the reduction of normal-tissue toxicity. Studies of the so-called FLASH effect have shown promise, generating huge interest in high dose rate radiation studies. With laser-driven proton beams, where the duration of the proton burst delivered to a sample can be as short as hundreds of picoseconds, the instantaneous dose rates are several orders of magnitude higher than those used for conventional radiotherapy. The dosimetry of these beam modalities is not trivial, with conventional active detectors, such as ionisation chambers, experiencing saturation effects making them unusable at the extremely high dose rates. Calorimeters, measuring the radiation-induced temperature rise in an absorber, offer an ideal candidate for the dosimetry of UHDR beams. However, their application in the measurement of laser-driven UHDR beams has so far not been trialled, and their effective suitability to work with the quasi-instantaneous and inhomogeneous dose deposition patterns and the harsh environment of a laser-plasma experiment has not been tested. The measurement of the absorbed dose of laser-driven proton beams was conducted in a first-of-its-kind investigation, employing the VULCAN-PW laser system of the Central Laser Facility (CLF) at the Rutherford Appleton Laboratory (RAL), using a small-body portable graphite calorimeter (SPGC) developed at the National Physical Laboratory (NPL) and radiochromic films. A small number of shots were recorded, with the corresponding absorbed dose measurements resulting from the induced temperature rise. The effect of the electromagnetic pulse (EMP) generated during laser–target interaction was assessed on the system, showing no significant effects on the derived signal-to-noise ratio. These proof-of-principle tests highlight the ability of calorimetry techniques to measure the absorbed dose for laser-driven proton beams.</description><identifier>ISSN: 2076-3417</identifier><identifier>EISSN: 2076-3417</identifier><identifier>DOI: 10.3390/app132111894</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>calorimetry ; Dosimetry ; Energy ; Graphite ; Heat ; Investigations ; laser-driven acceleration ; Lasers ; Radiation ; radiation dosimetry ; Radiation therapy ; Sensors ; Technology application</subject><ispartof>Applied sciences, 2023-11, Vol.13 (21), p.11894</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-3c3e06d01a2cfcf883860842d29571cac5cde533d63ea2462394f583a8a61a2b3</citedby><cites>FETCH-LOGICAL-c406t-3c3e06d01a2cfcf883860842d29571cac5cde533d63ea2462394f583a8a61a2b3</cites><orcidid>0000-0002-1044-1534 ; 0000-0002-3467-4631</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2888111619/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2888111619?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,25734,27905,27906,36993,44571,74875</link.rule.ids></links><search><creatorcontrib>McCallum, Sean</creatorcontrib><creatorcontrib>Lee, Nigel</creatorcontrib><creatorcontrib>Milluzzo, Giuliana</creatorcontrib><creatorcontrib>McIlvenny, Aodhan</creatorcontrib><creatorcontrib>Borghesi, Marco</creatorcontrib><creatorcontrib>Subiel, Anna</creatorcontrib><creatorcontrib>Romano, Francesco</creatorcontrib><title>Proof-of-Principle of Absolute Dosimetry Using an Absorbed Dose Portable Calorimeter with Laser-Driven Proton Beams</title><title>Applied sciences</title><description>Charged particle beams driven to ultra-high dose rates (UHDRs) have been shown to offer potential benefits for future clinical applications, particularly in the reduction of normal-tissue toxicity. Studies of the so-called FLASH effect have shown promise, generating huge interest in high dose rate radiation studies. With laser-driven proton beams, where the duration of the proton burst delivered to a sample can be as short as hundreds of picoseconds, the instantaneous dose rates are several orders of magnitude higher than those used for conventional radiotherapy. The dosimetry of these beam modalities is not trivial, with conventional active detectors, such as ionisation chambers, experiencing saturation effects making them unusable at the extremely high dose rates. Calorimeters, measuring the radiation-induced temperature rise in an absorber, offer an ideal candidate for the dosimetry of UHDR beams. However, their application in the measurement of laser-driven UHDR beams has so far not been trialled, and their effective suitability to work with the quasi-instantaneous and inhomogeneous dose deposition patterns and the harsh environment of a laser-plasma experiment has not been tested. The measurement of the absorbed dose of laser-driven proton beams was conducted in a first-of-its-kind investigation, employing the VULCAN-PW laser system of the Central Laser Facility (CLF) at the Rutherford Appleton Laboratory (RAL), using a small-body portable graphite calorimeter (SPGC) developed at the National Physical Laboratory (NPL) and radiochromic films. A small number of shots were recorded, with the corresponding absorbed dose measurements resulting from the induced temperature rise. The effect of the electromagnetic pulse (EMP) generated during laser–target interaction was assessed on the system, showing no significant effects on the derived signal-to-noise ratio. These proof-of-principle tests highlight the ability of calorimetry techniques to measure the absorbed dose for laser-driven proton beams.</description><subject>calorimetry</subject><subject>Dosimetry</subject><subject>Energy</subject><subject>Graphite</subject><subject>Heat</subject><subject>Investigations</subject><subject>laser-driven acceleration</subject><subject>Lasers</subject><subject>Radiation</subject><subject>radiation dosimetry</subject><subject>Radiation therapy</subject><subject>Sensors</subject><subject>Technology application</subject><issn>2076-3417</issn><issn>2076-3417</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpNUcFq3DAQNaGFhDS3fICg1zqVNLYsH7ebpg0sdA_NWYyl0UaL13Ilb0v-vtpsKRkEM8y89-ahqapbwe8Aev4Z51mAFELovrmoriTvVA2N6N69qS-rm5z3vEQvQAt-VeVtitHX5W1TmGyYR2LRs9WQ43hciN3HHA60pBf2lMO0Yzi9ztJA7jQjto1pwaGw1jjGdMJSYn_C8sw2mCnV9yn8pomVNUuc2BfCQ_5Qvfc4Zrr5l6-rp4evP9ff682Pb4_r1aa2DVdLDRaIK8cFSuut1xq04rqRTvZtJyza1jpqAZwCQtkoCX3jWw2oURXOANfV41nXRdybuZjD9GIiBvPaiGlnMC3BjmQ0odXSKesFNU6pnpTvBl0WC0eoqWh9PGvNKf46Ul7MPh7TVOwbqbUu365EX1B3Z9QOi2iYfFwSFqfo6BBsnMiH0l91nWxBAPBC-HQm2BRzTuT_2xTcnM5q3p4V_gL5ZpVC</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>McCallum, Sean</creator><creator>Lee, Nigel</creator><creator>Milluzzo, Giuliana</creator><creator>McIlvenny, Aodhan</creator><creator>Borghesi, Marco</creator><creator>Subiel, Anna</creator><creator>Romano, Francesco</creator><general>MDPI AG</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1044-1534</orcidid><orcidid>https://orcid.org/0000-0002-3467-4631</orcidid></search><sort><creationdate>20231101</creationdate><title>Proof-of-Principle of Absolute Dosimetry Using an Absorbed Dose Portable Calorimeter with Laser-Driven Proton Beams</title><author>McCallum, Sean ; Lee, Nigel ; Milluzzo, Giuliana ; McIlvenny, Aodhan ; Borghesi, Marco ; Subiel, Anna ; Romano, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-3c3e06d01a2cfcf883860842d29571cac5cde533d63ea2462394f583a8a61a2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>calorimetry</topic><topic>Dosimetry</topic><topic>Energy</topic><topic>Graphite</topic><topic>Heat</topic><topic>Investigations</topic><topic>laser-driven acceleration</topic><topic>Lasers</topic><topic>Radiation</topic><topic>radiation dosimetry</topic><topic>Radiation therapy</topic><topic>Sensors</topic><topic>Technology application</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCallum, Sean</creatorcontrib><creatorcontrib>Lee, Nigel</creatorcontrib><creatorcontrib>Milluzzo, Giuliana</creatorcontrib><creatorcontrib>McIlvenny, Aodhan</creatorcontrib><creatorcontrib>Borghesi, Marco</creatorcontrib><creatorcontrib>Subiel, Anna</creatorcontrib><creatorcontrib>Romano, Francesco</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Applied sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCallum, Sean</au><au>Lee, Nigel</au><au>Milluzzo, Giuliana</au><au>McIlvenny, Aodhan</au><au>Borghesi, Marco</au><au>Subiel, Anna</au><au>Romano, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proof-of-Principle of Absolute Dosimetry Using an Absorbed Dose Portable Calorimeter with Laser-Driven Proton Beams</atitle><jtitle>Applied sciences</jtitle><date>2023-11-01</date><risdate>2023</risdate><volume>13</volume><issue>21</issue><spage>11894</spage><pages>11894-</pages><issn>2076-3417</issn><eissn>2076-3417</eissn><abstract>Charged particle beams driven to ultra-high dose rates (UHDRs) have been shown to offer potential benefits for future clinical applications, particularly in the reduction of normal-tissue toxicity. Studies of the so-called FLASH effect have shown promise, generating huge interest in high dose rate radiation studies. With laser-driven proton beams, where the duration of the proton burst delivered to a sample can be as short as hundreds of picoseconds, the instantaneous dose rates are several orders of magnitude higher than those used for conventional radiotherapy. The dosimetry of these beam modalities is not trivial, with conventional active detectors, such as ionisation chambers, experiencing saturation effects making them unusable at the extremely high dose rates. Calorimeters, measuring the radiation-induced temperature rise in an absorber, offer an ideal candidate for the dosimetry of UHDR beams. However, their application in the measurement of laser-driven UHDR beams has so far not been trialled, and their effective suitability to work with the quasi-instantaneous and inhomogeneous dose deposition patterns and the harsh environment of a laser-plasma experiment has not been tested. The measurement of the absorbed dose of laser-driven proton beams was conducted in a first-of-its-kind investigation, employing the VULCAN-PW laser system of the Central Laser Facility (CLF) at the Rutherford Appleton Laboratory (RAL), using a small-body portable graphite calorimeter (SPGC) developed at the National Physical Laboratory (NPL) and radiochromic films. A small number of shots were recorded, with the corresponding absorbed dose measurements resulting from the induced temperature rise. The effect of the electromagnetic pulse (EMP) generated during laser–target interaction was assessed on the system, showing no significant effects on the derived signal-to-noise ratio. These proof-of-principle tests highlight the ability of calorimetry techniques to measure the absorbed dose for laser-driven proton beams.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/app132111894</doi><orcidid>https://orcid.org/0000-0002-1044-1534</orcidid><orcidid>https://orcid.org/0000-0002-3467-4631</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2076-3417
ispartof Applied sciences, 2023-11, Vol.13 (21), p.11894
issn 2076-3417
2076-3417
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_8eac82d6cf1e4d669e6f7b82cf1dea8e
source Publicly Available Content Database
subjects calorimetry
Dosimetry
Energy
Graphite
Heat
Investigations
laser-driven acceleration
Lasers
Radiation
radiation dosimetry
Radiation therapy
Sensors
Technology application
title Proof-of-Principle of Absolute Dosimetry Using an Absorbed Dose Portable Calorimeter with Laser-Driven Proton Beams
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T01%3A06%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Proof-of-Principle%20of%20Absolute%20Dosimetry%20Using%20an%20Absorbed%20Dose%20Portable%20Calorimeter%20with%20Laser-Driven%20Proton%20Beams&rft.jtitle=Applied%20sciences&rft.au=McCallum,%20Sean&rft.date=2023-11-01&rft.volume=13&rft.issue=21&rft.spage=11894&rft.pages=11894-&rft.issn=2076-3417&rft.eissn=2076-3417&rft_id=info:doi/10.3390/app132111894&rft_dat=%3Cgale_doaj_%3EA772531330%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c406t-3c3e06d01a2cfcf883860842d29571cac5cde533d63ea2462394f583a8a61a2b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2888111619&rft_id=info:pmid/&rft_galeid=A772531330&rfr_iscdi=true