Anionic Surfactant Based Topical Curcumin Nanosuspension: Fabrication, Characterization and Evaluation

Curcumin, a hydrophobic polyphenol isolated from dried rhizomes of turmeric exhibits diverse pharmacological activities including anti-bacterial. However, the clinical usefulness of curcumin was limited mainly due to low aqueous solubility and stability. The primary aim of the study was to prepare a...

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Bibliographic Details
Published in:Nano biomedicine and engineering 2013-06, Vol.5 (2), p.86-89
Main Authors: Chidambaram, Moorthi, Chinnamaruthu, Senthilkumar, Sellappan, Mohan, Krishnasamy, Kathiresan
Format: Article
Language:English
Subjects:
anionic surfactant
curcumin
nanoprecipitation method
nanosuspension
sodium lauryl sulfate
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Summary:Curcumin, a hydrophobic polyphenol isolated from dried rhizomes of turmeric exhibits diverse pharmacological activities including anti-bacterial. However, the clinical usefulness of curcumin was limited mainly due to low aqueous solubility and stability. The primary aim of the study was to prepare anionic surfactant based curcumin nanosuspension and to assess its in-vitro anti-bacterial efficacy on Escherichia coli in comparison with ethanolic solution of curcumin. Curcumin nanosuspension was prepared by nanoprecipitation method, characterized for the average particle size, span, uniformity, surface area, and surface morphology and assessed for its anti-bacterial activity against gram-negative bacteria Escherichia coli using agar well diffusion method. Prepared curcumin nanosuspension showed an average particle size of about 175 nm, span of about 1.5, uniformity of about 0.8, surface area of about 57 m2/g and nanoparticles were spherical in shape. Curcumin nanosuspension have shown significant (P
ISSN:2150-5578
2150-5578
DOI:10.5101/nbe.v5i2.p86-89