Fluorescent chemosensors for toxic organophosphorus pesticides: a review

Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are r...

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Published in:Sensors (Basel, Switzerland) Switzerland), 2010-07, Vol.10 (7), p.7018-7043
Main Authors: Obare, Sherine O, De, Chandrima, Guo, Wen, Haywood, Tajay L, Samuels, Tova A, Adams, Clara P, Masika, Noah O, Murray, Desmond H, Anderson, Ginger A, Campbell, Keith, Fletcher, Kenneth
Format: Article
Language:English
Subjects:
dual modes of signal transduction
fluorescent chemosensors
Fluorescent Dyes - analysis
organophosphorus compounds
Organophosphorus Compounds - analysis
Pesticides - analysis
pollutants
Review
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Summary:Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are related to the more reactive phosphoryl (P=O) organophosphates, which include very lethal nerve agents and chemical warfare agents, such as, VX, Soman and Sarin. Unfortunately, widespread and frequent commercial use of OP-based compounds in agricultural lands has resulted in their presence as residues in crops, livestock, and poultry products and also led to their migration into aquifers. Thus, the design of new sensors with improved analyte selectivity and sensitivity is of paramount importance in this area. Herein, we review recent advances in the development of fluorescent chemosensors for toxic OP pesticides and related compounds. We also discuss challenges and progress towards the design of future chemosensors with dual modes for signal transduction.
ISSN:1424-8220
1424-8220
DOI:10.3390/s100707018