PU.1 and Haematopoietic Cell Fate: Dosage Matters

The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will disc...

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Bibliographic Details
Published in:International Journal of Cell Biology 2011, Vol.2011 (2011), p.207-212
Main Authors: Mak, Ka Sin, Funnell, Alister P. W., Pearson, Richard C. M., Crossley, Merlin
Format: Article
Language:English
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Review
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Summary:The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced our knowledge of the mechanisms by which PU.1 drives lineage-specific differentiation during haematopoiesis.
ISSN:1687-8876
1687-8884
DOI:10.1155/2011/808524