Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis

The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despi...

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Bibliographic Details
Published in:Case reports in critical care 2018, Vol.2018 (2018), p.1-4
Main Authors: Bussani, Rossana, Leonardo, Eugenio, Zandonà, Lorenzo, Tomasini, Ariella, Berlot, Giorgio, Zarrillo, Nadia
Format: Article
Language:English
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Case Report
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Summary:The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered.
ISSN:2090-6420
2090-6439
DOI:10.1155/2018/9756050