Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase-2 (COX-2) Inhibitory Activities

Eight new triterpenoids were isolated from Ainsliaea latifolia. The structures of these compounds were elucidated by interpretation of spectroscopic data, including HRESIMS and NMR data. Compounds 4 – 6 are identified as rare trinorcucurbitane or tetranorcucurbitane triterpenoids. The absolute confi...

Full description

Saved in:
Bibliographic Details
Published in:Natural products and bioprospecting 2020-02, Vol.10 (1), p.13-21
Main Authors: Yuan, Wen-Lin, Dong, Xue-Yun, Huang, Zheng-Rui, Xiao, Si-Jia, Ye, Ji, Tian, Xin-Hui, Li, Hui-Liang, Shen, Yun-Heng, Zhang, Wei-Dong
Format: Article
Language:English
Subjects:
Ainsliaea latifolia
Biomedical and Life Sciences
Bioorganic Chemistry
COX-2
Cucurbitane
Cyclooxygenase-2
Food Science
Life Sciences
Medicinal Chemistry
NMR
Nuclear magnetic resonance
Original
Original Article
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Triterpenoids
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Eight new triterpenoids were isolated from Ainsliaea latifolia. The structures of these compounds were elucidated by interpretation of spectroscopic data, including HRESIMS and NMR data. Compounds 4 – 6 are identified as rare trinorcucurbitane or tetranorcucurbitane triterpenoids. The absolute configurations of compounds 1 and 2 were confirmed by Snatzke’s method. All compounds were evaluated for their inhibition against cyclooxyenase-2 (COX-2), in which compound 4 showed significant inhibitory effect against COX-2 with IC 50 value of 3.98 ± 0.32 μM, comparable to that of positive control NS-398 (IC 50 4.14 ± 0.28 μM). Graphic Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-019-00228-x