NF-kB affects migration of vascular smooth muscle cells after treatment with heparin and ibrutinib

The migration of vascular smooth muscle cells (VSMCs) is one of the most important events in the remodeling of atherosclerosis plaque. The aim of study was to investigate the role of Heparin in the VSMC migration and its association with the NF-kB, collagen 1 and collagen 3 expression levels. Moreov...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry and biophysics reports 2024-07, Vol.38, p.101685-101685, Article 101685
Main Authors: Shokri, Nafiseh, Ghasempour, Ghasem, Soleimani, Ali Akbar, Elahimanesh, Mohammad, Najafi, Mohammad
Format: Article
Language:English
Subjects:
Betulinic acid
Collagen
Heparin
Ibrutinib
NF-kB
VSMCs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The migration of vascular smooth muscle cells (VSMCs) is one of the most important events in the remodeling of atherosclerosis plaque. The aim of study was to investigate the role of Heparin in the VSMC migration and its association with the NF-kB, collagen 1 and collagen 3 expression levels. Moreover, the incorporation of Heparin was studied in the VSMC cultures including Betulinic acid and Ibrutinib. Twelve cell groups were cultured and treated with the Heparin, Betulinic acid and Ibrutinib based on the viability and toxicity in 24-h and 48-h periods. The gene and protein expression levels were measured by RT-qPCR and western blotting techniques. The VSMC migration was determined by scratch test. In contrast with Ibrutinib (2 μM), Heparin (30 IU) increased significantly (P 
ISSN:2405-5808
2405-5808
DOI:10.1016/j.bbrep.2024.101685