Role of TREK-1 in Health and Disease, Focus on the Central Nervous System

TREK-1 is the most studied background K channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of depolarization. TREK-1 is multi-regulated by a variety of physical and chemical stimuli which makes it a very promising and challenging target in...

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Bibliographic Details
Published in:Frontiers in pharmacology 2019-04, Vol.10, p.379-379
Main Authors: Djillani, Alaeddine, Mazella, Jean, Heurteaux, Catherine, Borsotto, Marc
Format: Article
Language:English
Subjects:
ion channel
K2P
Life Sciences
modulators
Neurobiology
neurological disorders
Neurons and Cognition
Pharmacology
potassium
TREK-1
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Summary:TREK-1 is the most studied background K channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of depolarization. TREK-1 is multi-regulated by a variety of physical and chemical stimuli which makes it a very promising and challenging target in the treatment of several pathologies. It is mainly expressed in the brain but also in heart, smooth muscle cells, endocrine pancreas, and prostate. In the nervous system, TREK-1 is involved in many physiological and pathological processes such as depression, neuroprotection, pain, and anesthesia. These properties explain why many laboratories and pharmaceutical companies have been focusing their research on screening and developing highly efficient modulators of TREK-1 channels. In this review, we summarize the different roles of TREK-1 that have been investigated so far in attempt to characterize pharmacological tools and new molecules to modulate cellular functions controlled by TREK-1.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2019.00379