Metabolic Origins of Heart Failure

Summary For more than half a century, metabolic perturbations have been explored in the failing myocardium, highlighting a reversion to a more fetal-like metabolic profile (characterized by depressed fatty acid oxidation and concomitant increased reliance on use of glucose). More recently, alteratio...

Full description

Saved in:
Bibliographic Details
Published in:JACC. Basic to translational science 2017-06, Vol.2 (3), p.297-310
Main Authors: Wende, Adam R., PhD, Brahma, Manoja K., PhD, McGinnis, Graham R., PhD, Young, Martin E., DPhil
Format: Article
Language:English
Subjects:
amino acids
Cardiovascular
fatty acids
glucose
heart failure
ketone bodies
STATE-OF-THE-ART REVIEW
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary For more than half a century, metabolic perturbations have been explored in the failing myocardium, highlighting a reversion to a more fetal-like metabolic profile (characterized by depressed fatty acid oxidation and concomitant increased reliance on use of glucose). More recently, alterations in ketone body and amino acid/protein metabolism have been described during heart failure, as well as mitochondrial dysfunction and perturbed metabolic signaling (e.g., acetylation, O -GlcNAcylation). Although numerous mechanisms are likely involved, the current review provides recent advances regarding the metabolic origins of heart failure, and their potential contribution toward contractile dysfunction of the heart.
ISSN:2452-302X
2452-302X
DOI:10.1016/j.jacbts.2016.11.009