Quality of life in patients with primary biliary cholangitis: A cross-geographical comparison

Several symptoms impair the quality of life (QoL) of patients with primary biliary cholangitis (PBC). They are reported to vary significantly in different countries. Aim of our study was to explore whether there is a geographical clustering that accounts for symptoms in PBC. Data was analysed from f...

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Published in:Journal of translational autoimmunity (Online) 2021-01, Vol.4, p.100081-100081, Article 100081
Main Authors: Montali, Lorenzo, Gragnano, Andrea, Miglioretti, Massimo, Frigerio, Alessandra, Vecchio, Luca, Gerussi, Alessio, Cristoferi, Laura, Ronca, Vincenzo, D’Amato, Daphne, O’Donnell, Sarah Elizabeth, Mancuso, Clara, Lucà, Martina, Yagi, Minami, Reig, Anna, Jopson, Laura, Pilar, Sesé, Jones, Dave, Pares, Albert, Mells, George, Tanaka, Atsushi, Carbone, Marco, Invernizzi, Pietro
Format: Article
Language:English
Subjects:
Autoimmunity
Cholestasis
Fatigue
Liver
Research paper
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Summary:Several symptoms impair the quality of life (QoL) of patients with primary biliary cholangitis (PBC). They are reported to vary significantly in different countries. Aim of our study was to explore whether there is a geographical clustering that accounts for symptoms in PBC. Data was analysed from four cohorts of PBC patients from the UK, Spain, Japan and Italy using the PBC-27 scale. Overall, 569 patients from four cohorts were identified, including 515 females (90.5%) with a mean age of 61 years. The analysis provided evidence for strict factorial invariance of the scale, a robust indicator of its validity for cross-cultural research. The mean of the fatigue domain of British patients was significantly greater than that of the Japanese (p ​
ISSN:2589-9090
2589-9090
DOI:10.1016/j.jtauto.2021.100081