Ethanol extract of Vitellaria paradoxa (Gaertn, F) leaves protects against sodium arsenite - induced toxicity in male wistar rats

[Display omitted] •Ethanol leaf extract of Vitellaria paradoxa (ELVp) suppressed Sodium Arsenite (SA)-induced toxicity in male Wistar rats.•ELVp prevented SA-induced lipid peroxidation.•ELVp may induced apoptosis by elevating p53 and reducing BCL-2 expression.•ELVp has hepatoprotective and nephropro...

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Bibliographic Details
Published in:Toxicology reports 2021-01, Vol.8, p.774-784
Main Authors: Oyibo, Aghogho, Gbadegesin, Michael A., Odunola, Oyeronke A.
Format: Article
Language:English
Subjects:
Hepatotoxicity
Nephrotoxicity
Regular
Sodium arsenite
Vitellaria paradoxa
Wistar rats
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Summary:[Display omitted] •Ethanol leaf extract of Vitellaria paradoxa (ELVp) suppressed Sodium Arsenite (SA)-induced toxicity in male Wistar rats.•ELVp prevented SA-induced lipid peroxidation.•ELVp may induced apoptosis by elevating p53 and reducing BCL-2 expression.•ELVp has hepatoprotective and nephroprotective properties against SA-induced toxicities. The inadvertent exposure to arsenic has been associated with diverse diseases such as cancers. Vitellaria paradoxa is a medicinal plant with antidiabetic and antiproliferative properties. Here, we assessed the ameliorative role of Ethanol Leaf extract of Vitellaria paradoxa (ELVp) in Sodium Arsenite (SA) - induced toxicity in rats after oral treatment for two weeks as follows: Group 1 (Control, distilled water), Group 2 (Vitamin E, 100 mg/kg), Groups 3 and 4 (ELVp, 100 & 200 mg/kg respectively), Group 5 (SA, 2.5 mg/kg), Group 6 (SA + Vit E) and Group 7 (SA + ELVp (100 mg/kg) and Group 8 (SA + ELVp (200 mg/kg). The results indicated that SA significantly increased liver and kidney function markers and elevated platelet, white blood cell (WBC) count and malondialdehyde levels in rats. Additionally, SA decreased Red Blood Cell (RBC), Hemoglobin (HGB) and Hematocrit (HCT) levels in rats (p < 0.05). Sodium arsenite caused mild expression of BCL-2 protein> NF-Kb = p53 in the kidney of rats. However, ELVp ameliorated SA-induced toxicity in the liver and kidney of rats with respect to these markers. Overall, ELVp has hepatoprotective, nephroprotective and apoptotic properties against sodium arsenite-induced toxicity.
ISSN:2214-7500
2214-7500
DOI:10.1016/j.toxrep.2021.03.035